Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | TOP1 | P11387 | 2/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1692394 | 0.85 | DHODH (0.44) | KDM4EALDH1A1HPGDMMP2DAO | |
| SCHEMBL6004302 | 0.84 | KDM4E (0.43) | MAPK14KDM4ERIPK1ALDH1A1HPGD | |
| SCHEMBL3892242 | 0.84 | COMT (0.43) | KDM4ERIPK1ALDH1A1HPGDKMT2A | |
| SCHEMBL6004749 | 0.84 | CYP1A2 (0.41) | MAPK14KDM4ERIPK1ALDH1A1HPGD | |
| SCHEMBL6004768 | 0.84 | KDM4E (0.51) | MAPK14KDM4EALDH1A1HPGDMAPK10 | |
| SCHEMBL2302926 | 0.81 | MAPK14 (0.52) | MAPK14ALDH1A1HPGDPIK3CAMAPK10 | |
| SCHEMBL6004176 | 0.81 | SLC22A12 (0.41) | — | |
| SCHEMBL6004865 | 0.78 | L3MBTL1 (0.54) | KDM4EALDH1A1DAONPC1RAB9A | |
| SCHEMBL30060806 | 0.76 | KDM4E (0.43) | KDM4EALDH1A1HPGDMEN1NPC1 | |
| SCHEMBL3891471 | 0.76 | MAPK14 (0.53) | MAPK14KDM4EALDH1A1HPGDMAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |