Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 5/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.43 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1692394 | 0.85 | DHODH (0.44) | L3MBTL1KDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL6004768 | 0.84 | KDM4E (0.51) | L3MBTL1KDM4ENPC1RAB9AEGFR | |
| SCHEMBL3892242 | 0.78 | COMT (0.43) | L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL6004845 | 0.78 | MAPK14 (0.52) | KDM4ENPC1RAB9AALDH1A1DAO | |
| SCHEMBL6004302 | 0.78 | KDM4E (0.43) | L3MBTL1KDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL6004749 | 0.78 | CYP1A2 (0.41) | L3MBTL1KDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL6002944 | 0.77 | AURKA (0.53) | KDM4ECYP19A1ALDH1A1ABCG2 | |
| SCHEMBL6005315 | 0.76 | EGFR (0.51) | L3MBTL1KDM4ENPC1RAB9AEGFR | |
| SCHEMBL6004176 | 0.75 | SLC22A12 (0.41) | CYP11B1CYP11B2CYP17A1ABCG2 | |
| SCHEMBL30216796 | 0.74 | CYP2A6 (0.61) | L3MBTL1KDM4ENPC1RAB9AEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |