Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | COMT | P21964 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | QDPR | P09417 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1692394 | 0.88 | DHODH (0.44) | KDM4EL3MBTL1NPC1RAB9AALDH1A1 | |
| SCHEMBL6004845 | 0.84 | MAPK14 (0.52) | KDM4ENPC1RAB9AMAPK14ALDH1A1 | |
| SCHEMBL6004749 | 0.84 | CYP1A2 (0.41) | KDM4EL3MBTL1NPC1RAB9AMAPK14 | |
| SCHEMBL6004302 | 0.84 | KDM4E (0.43) | KDM4EL3MBTL1NPC1RAB9AMAPK14 | |
| SCHEMBL3892242 | 0.84 | COMT (0.43) | KDM4EL3MBTL1ALDH1A1HPGDCOMT | |
| SCHEMBL6004865 | 0.84 | L3MBTL1 (0.54) | KDM4EL3MBTL1NPC1RAB9APDGFRB | |
| SCHEMBL6004176 | 0.80 | SLC22A12 (0.41) | — | |
| SCHEMBL3896975 | 0.77 | KDM4E (0.45) | KDM4EL3MBTL1NPC1RAB9AALDH1A1 | |
| SCHEMBL6002944 | 0.76 | AURKA (0.53) | KDM4EALDH1A1HPGDHDAC8 | |
| SCHEMBL30060806 | 0.76 | KDM4E (0.43) | KDM4EL3MBTL1NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |