Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.44 |
| ▸ | CCKBR | P32239 | 12/20 | 0.44 |
| ▸ | CCKAR | P32238 | 10/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6003776 | 0.84 | GABRP (0.44) | KCNH2CCKBRCCKAR | |
| SCHEMBL6004989 | 0.84 | GABRP (0.44) | KCNH2CCKBRCCKAR | |
| SCHEMBL6003648 | 0.77 | CCKAR (0.44) | CCKBRCCKAR | |
| SCHEMBL8846479 | 0.74 | CCKBR (0.64) | KCNH2CCKBRCCKAR | |
| SCHEMBL7871697 | 0.73 | CYP3A4 (0.55) | KCNH2CCKBRCCKAR | |
| SCHEMBL7212252 | 0.73 | CCKAR (0.64) | KCNH2CCKBRCCKAR | |
| SCHEMBL4701488 | 0.72 | GABRP (0.50) | CCKBRCCKAR | |
| SCHEMBL11471406 | 0.72 | OPRK1 (0.52) | KCNH2CCKBRCCKAR | |
| SCHEMBL11464229 | 0.72 | CCKAR (0.39) | KCNH2CCKBRCCKAR | |
| SCHEMBL9525412 | 0.71 | CCKBR (0.76) | CCKBRCCKAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7105509-B2 | Benzodiazepine derivatives as APP modulators | MERCK SHARP & DOHME LIMITED (GB) | 2006-09-12 | — | — | US | disclosed |
| US-20040082572-A1 | Benzodiazepine derivatives as app modulators | MERCK SHARPE & DOHME LIMITED (GB) | 2004-04-29 | — | — | US | disclosed |
| EP-1294702-A1 | BENZODIAZEPINE DERIVATIVES AS APP MODULATORS | MERCK SHARP & DOHME LTD. (GB) | 2003-03-26 | — | — | EP | disclosed |
| WO-2001090084-A1 | BENZODIAZEPINE DERIVATIVES AS APP MODULATORS | MERCK SHARP & DOHME LIMITED (GB) | 2001-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082572-A1 | Benzodiazepine derivatives as app modulators | BACE1, PSEN1, APP | KCNH2 1795/4885CCKBR 642/4885CCKAR 838/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.