Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 5/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6002912 | 0.86 | TGFBR1 (0.48) | EGFRTGFBR1L3MBTL1NPC1MAPT | |
| SCHEMBL6002928 | 0.85 | TGFBR1 (0.40) | EGFRKDRTGFBR1MAPT | |
| SCHEMBL3895797 | 0.84 | KDR (0.47) | EGFRKDRALDH1A1 | |
| SCHEMBL3905940 | 0.84 | TGFBR1 (0.40) | TGFBR1 | |
| SCHEMBL6004166 | 0.75 | TGFBR1 (0.45) | EGFRKDRTGFBR1NPC1CYP1A2 | |
| SCHEMBL6002915 | 0.75 | TGFBR1 (0.45) | EGFRTGFBR1RAB9ANPC1CYP1A2 | |
| SCHEMBL6004756 | 0.74 | TGFBR1 (0.56) | EGFRTGFBR1RAB9ANPC1MAPT | |
| SCHEMBL6004691 | 0.73 | TGFBR1 (0.52) | EGFRKDRTGFBR1 | |
| SCHEMBL3895539 | 0.71 | SRC (0.51) | KDRTGFBR1 | |
| SCHEMBL6004307 | 0.71 | TGFBR1 (0.52) | TGFBR1L3MBTL1NPC1MAPTRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |