Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 3/20 | 0.40 |
| ▸ | KDR | P35968 | 5/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 2/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.38 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 2/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 6/20 | 0.36 |
| ▸ | LCK | P06239 | 2/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3895797 | 0.87 | KDR (0.47) | KDRTRPA1CSF1RPDGFRBFLT4 | |
| SCHEMBL6004756 | 0.85 | TGFBR1 (0.56) | TGFBR1BRAFRAF1CSF1RPDGFRB | |
| SCHEMBL6005338 | 0.85 | EGFR (0.40) | TGFBR1KDRMAPTEGFR | |
| SCHEMBL6004691 | 0.72 | TGFBR1 (0.52) | TGFBR1KDRTRPA1CSF1REGFR | |
| SCHEMBL3895539 | 0.72 | SRC (0.51) | TGFBR1KDRPDGFRBPDGFRA | |
| SCHEMBL3905940 | 0.72 | TGFBR1 (0.40) | TGFBR1BRAF | |
| SCHEMBL6004185 | 0.72 | TGFBR1 (0.59) | TGFBR1MAPT | |
| SCHEMBL6002915 | 0.72 | TGFBR1 (0.45) | TGFBR1CSF1RMAPTEGFRLCK | |
| SCHEMBL6004166 | 0.72 | TGFBR1 (0.45) | TGFBR1KDRMAPTEGFR | |
| SCHEMBL6002912 | 0.71 | TGFBR1 (0.48) | TGFBR1MAPTEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |