Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 13/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 2/20 | 0.34 |
| ▸ | CBFB | Q13951 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6005388 | 0.92 | TGFBR1 (0.48) | TGFBR1KDM4ENPC1MAOA | |
| SCHEMBL6002919 | 0.89 | SLC22A12 (0.38) | TGFBR1SLC22A12MAOAPDE2APDE10A | |
| SCHEMBL6005265 | 0.87 | TGFBR1 (0.44) | TGFBR1KDM4ENPC1SLC22A12MAOA | |
| SCHEMBL6004185 | 0.87 | TGFBR1 (0.59) | TGFBR1KDM4ENPC1 | |
| SCHEMBL6004274 | 0.86 | TGFBR1 (0.48) | TGFBR1KDM4ENPC1MAOA | |
| SCHEMBL3903240 | 0.85 | TGFBR1 (0.49) | TGFBR1SRC | |
| SCHEMBL6004761 | 0.85 | TGFBR1 (0.49) | TGFBR1SRC | |
| SCHEMBL6005291 | 0.85 | TGFBR1 (0.48) | TGFBR1KDM4ENPC1SRC | |
| SCHEMBL6004725 | 0.84 | TGFBR1 (0.48) | TGFBR1KDM4ENPC1SRCCBFB | |
| SCHEMBL6004207 | 0.84 | CYP1A2 (0.37) | TGFBR1KDM4ENPC1SLC22A12CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |