Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL576001 | 0.85 | CA1 (0.33) | TSHRALDH1A1LMNAMMP9 | |
| SCHEMBL29128556 | 0.84 | ALDH1A1 (0.39) | USP2TSHRKDM4EALDH1A1LMNA | |
| SCHEMBL18126472 | 0.80 | USP2 (0.39) | USP2TSHRKDM4EALDH1A1LMNA | |
| SCHEMBL1043228 | 0.79 | USP2 (0.39) | USP2TSHRKDM4EALDH1A1LMNA | |
| SCHEMBL18126379 | 0.78 | FAAH (0.39) | ALDH1A1LMNA | |
| SCHEMBL18126342 | 0.78 | USP2 (0.38) | USP2TSHRKDM4EALDH1A1LMNA | |
| SCHEMBL18126397 | 0.76 | FAAH (0.42) | — | |
| SCHEMBL15868137 | 0.76 | CA2 (0.32) | TSHR | |
| SCHEMBL11195053 | 0.76 | LMNA (0.38) | USP2TSHRKDM4EALDH1A1LMNA | |
| SCHEMBL18126340 | 0.76 | FAAH (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105130986-B | Pyrimidine or pyridopyridine ketone compounds and its application | 广州科擎新药开发有限公司 | 2017-07-18 | — | — | CN | disclosed |
| CN-105130986-A | Pyrimidine or pyridino-pyridone compound and application thereof | GUANGZHOU KEQIN NEW MEDICINE DEV CO LTD | 2015-12-09 | — | — | CN | disclosed |
| CN-104151216-A | Synthetic method of lapatinib side chain | SHANDONG BOYUAN PHARMACEUTICAL CO LTD | 2014-11-19 | — | — | CN | disclosed |
| EP-1406869-B1 | TAXOL ENHANCER COMPOUNDS | SYNTA PHARMACEUTICALS CORP (US) | 2006-09-13 | — | — | EP | disclosed |
| CN-1143856-C | Novel substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) [1,4] diazepan-1-yl)-1-(aryl) butyl) benzamides useful for treatment of allergic diseases | ���µ�˹ҩ�﹫˾ | 2004-03-31 | — | — | CN | disclosed |
| CN-1115341-C | Novel substituted N-methyl-N- (4- (4- (1H-benzimidazol-2-ylamino) piperidin-1-yl) -2- (aryl) butyl) benzamides for the treatment of allergic diseases | AVENTIS PHARMACEUTICALS CORP (US) | 2003-07-23 | — | — | CN | disclosed |
| CN-1080262-C | Novel substituted 4-(1H-benzimidazol-2-YL) [1,4] diazepanes useful for the treatment of allergic diseases | HOECHST MARION ROUSSEL INC (US) | 2002-03-06 | — | — | CN | disclosed |
| CN-1211246-A | Novel substituted N-methyl-N-(4-(1H-benzimidazol-2-yl-amino) piperidin-1-yl)-2-(aryl) butyl) benzamides useful for treatment of allergic diseases | HOECHST MARION ROUSSEL INC (US) | 1999-03-17 | — | — | CN | disclosed |
| CN-1211248-A | Novel substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) [1,4] diazepan-1-yl)-1-(aryl) butyl) benzamides useful for treatment of allergic diseases | HOECHST MARION ROUSSEL INC (US) | 1999-03-17 | — | — | CN | disclosed |
| CN-1207097-A | Novel substituted 4- (1H-benzimidazol-2-yl) [1,4] diazepanes useful for the treatment of allergic diseases | HOECHST MARION ROUSSEL INC (US) | 1999-02-03 | — | — | CN | disclosed |
| WO-1998008508-A1 | USE OF PKC INHIBITORS FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF HTLV-1 INFECTIONS | ELI LILLY AND COMPANY (US) | 1998-03-05 | — | — | WO | disclosed |
| EP-0165784-B1 | ISOXAZOLE AND ISOTHIAZOLE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1989-11-23 | — | — | EP | disclosed |
| US-4001247-A | 1-ETHYL 3A-(SUBSTITUTED-PHENYL) DECAHYDROISOQUINOLINE | ELI LILLY AND COMPANY (US) | 1977-01-04 | — | — | US | disclosed |