Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CCR6 | P51684 | 1/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 3/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3369760 | 0.71 | SMN1; SMN2 (0.47) | CYP11B1CYP11B2PTGS2SMN1; SMN2HTT | |
| SCHEMBL3369758 | 0.71 | SMN1; SMN2 (0.47) | CYP11B1CYP11B2PTGS2SMN1; SMN2HTT | |
| SCHEMBL10951291 | 0.70 | PTGS2 (0.57) | CYP11B1CYP11B2PTGS2SMN1; SMN2HTT | |
| SCHEMBL5458774 | 0.70 | PTGS2 (0.57) | CYP11B1CYP11B2PTGS2SIRT2CA12 | |
| SCHEMBL803901 | 0.70 | PTGS2 (0.68) | CYP11B1CYP11B2PTGS2CA12CA1 | |
| SCHEMBL23928537 | 0.68 | MAPT (0.67) | PTGS2SMN1; SMN2HTTKMT2AFAAH | |
| SCHEMBL4190362 | 0.65 | PTGS2 (0.72) | CYP11B1CYP11B2PTGS2CA12CA1 | |
| SCHEMBL9529534 | 0.64 | HTT (0.48) | SMN1; SMN2HTTKMT2ACACNA1BCA12 | |
| SCHEMBL13892893 | 0.64 | MMP2 (0.52) | SMN1; SMN2CA12CA1CA2CA9 | |
| SCHEMBL9034923 | 0.64 | PTGS2 (0.55) | PTGS2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656347-A1 | SUBSTITUTED INDOLE DERIVATIVES FOR PHARMACEUTICAL COMPOSITION FOR TREATING RESPIRATORY DISEASES | Astrazeneca AB (SE) | 2006-05-17 | — | — | EP | disclosed |
| WO-2005019171-A1 | SUBSTITUTED INDOLE DERIVATIVES FOR PHARMACEUTICAL COMPOSITION FOR TREATING RESPIRATORY DISEASES | ASTRAZENECA AB (SE) | 2005-03-03 | — | — | WO | disclosed |