Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.57 |
| ▸ | CA1 | P00915 | 3/20 | 0.50 |
| ▸ | CA2 | P00918 | 3/20 | 0.50 |
| ▸ | KDM1A | O60341 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 3/20 | 0.49 |
| ▸ | CA12 | O43570 | 2/20 | 0.49 |
| ▸ | CA9 | Q16790 | 2/20 | 0.49 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.47 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.45 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL803901 | 0.88 | PTGS2 (0.68) | PTGS2CA1CA2KDM1ACA12 | |
| SCHEMBL25667539 | 0.84 | ENPP2 (0.54) | CA1CA2CA12CA9PIP4K2A | |
| SCHEMBL4190362 | 0.82 | PTGS2 (0.72) | PTGS2CA1CA2CA12CA9 | |
| SCHEMBL4187483 | 0.82 | ALPL (0.49) | PTGS2CA1CA2CA12CA9 | |
| SCHEMBL27888182 | 0.81 | CA1 (0.71) | CA1CA2CA12CA9IKBKB | |
| SCHEMBL27374894 | 0.81 | SOS1 (0.51) | PTGS2PIP4K2A | |
| SCHEMBL30751412 | 0.81 | SOS1 (0.51) | PTGS2PIP4K2A | |
| SCHEMBL395539 | 0.79 | CA2 (0.52) | CA1CA2IDO1CA12CA9 | |
| SCHEMBL10951291 | 0.78 | PTGS2 (0.57) | PTGS2CA1CA2CA12CA9 | |
| SCHEMBL17492799 | 0.77 | MAPT (0.49) | CA1CA2CA12SIRT2CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070129433-A1 | Diphenylamine derivatives | MERCK PATENT GMBH (DE) | 2007-06-07 | — | — | US | claimed |
| EP-1687253-A2 | DIPHENYLAMINE DERIVATIVES | Merk Patent Gmbh (DE) | 2006-08-09 | — | — | EP | claimed |
| WO-2005051888-A2 | DIPHENYLAMINE DERIVATIVES | MERK PATENT GMBH (DE) | 2005-06-09 | — | — | WO | claimed |
| US-20070129433-A1 | Diphenylamine derivatives | MERCK PATENT GMBH (DE) | 2007-06-07 | — | — | US | disclosed |
| US-20070129433-A1 | Diphenylamine derivatives | MERCK PATENT GMBH (DE) | 2007-06-07 | — | — | US | disclosed |
| US-20070123586-A1 | Nitroso derivatives of diphenylamine | MERCK PATENT GMBH (DE) | 2007-05-31 | — | — | US | disclosed |
| US-20070123586-A1 | Nitroso derivatives of diphenylamine | MERCK PATENT GMBH (DE) | 2007-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070123586-A1 | Nitroso derivatives of diphenylamine | NOS3, CBR3, CBR1 | PTGS2 580/4885CA1 2615/4885CA2 1737/4885 |
| US-20070129433-A1 | Diphenylamine derivatives | CCNY, CHKB, CHKA | PTGS2 4190/4885CA1 1145/4885CA2 346/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.