Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sulfadimethoxine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.80 |
| ▸ | LMNA | P02545 | 2/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.80 |
| ▸ | HTR6 | P50406 | 1/20 | 0.80 |
| ▸ | AKT1 | P31749 | 3/20 | 0.66 |
| ▸ | HTT | P42858 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.63 |
| ▸ | POLB | P06746 | 3/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.54 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfadimethoxine SCHEMBL29363944 | 0.90 | LMNA (1.00) | ALDH1A1LMNACYP3A4HTR6AKT1 | |
| Sulfadimethoxine SCHEMBL93845 | 0.90 | LMNA (1.00) | ALDH1A1LMNACYP3A4HTR6AKT1 | |
| Sulfadimethoxine SCHEMBL2430279 | 0.89 | LMNA (0.97) | ALDH1A1LMNACYP3A4HTR6AKT1 | |
| Sulfadimethoxine SCHEMBL9486265 | 0.85 | ALDH1A1 (0.90) | ALDH1A1LMNACYP3A4HTR6AKT1 | |
| Sulfadimethoxine SCHEMBL13372563 | 0.84 | ALDH1A1 (0.76) | ALDH1A1LMNACYP3A4HTR6AKT1 | |
| SCHEMBL5449670 | 0.83 | ALDH1A1 (0.73) | ALDH1A1LMNACYP3A4HTR6AKT1 | |
| SCHEMBL10031613 | 0.83 | ALDH1A1 (0.80) | ALDH1A1LMNACYP3A4HTR6AKT1 | |
| SCHEMBL328330 | 0.82 | ALDH1A1 (0.74) | ALDH1A1LMNACYP3A4HTR6AKT1 | |
| Sulfadimethoxine SCHEMBL23928724 | 0.80 | ALDH1A1 (0.80) | ALDH1A1LMNACYP3A4HTR6AKT1 | |
| Sulfadimethoxine SCHEMBL17102809 | 0.80 | LMNA (0.80) | ALDH1A1LMNACYP3A4HTR6AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1386935-B1 | Dual stimuli-responsive hydrogels and their synthetic methods | KOREA INST SCI & TECH (KR) | 2006-01-25 | — | — | EP | disclosed |
| US-6784266-B2 | BLOCK POLYMERS HAVING BOTH THERMO- AND PH- RESPONSIVE PROPERTIES NECESSARY FOR DRUG DELIVERY SYSTEMS; COPOLYMERS BASED ON A SULFONAMIDE DERIVATIVE OF STYRENE (PH) AND N-ISOPROPYLACRYLAMIDE (HEAT); SULFA DRUGS | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2004-08-31 | — | — | US | disclosed |
| US-20040024096-A1 | Dual stimuli-responsive hydrogels and their synthetic methods | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2004-02-05 | — | — | US | disclosed |
| EP-1386935-A1 | Dual stimuli-responsive hydrogels and their synthetic methods | Korea Institute of Science and Technology (KR) | 2004-02-04 | — | — | EP | disclosed |