Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sulfadimethoxine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.90 |
| ▸ | LMNA | P02545 | 3/20 | 0.90 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.90 |
| ▸ | HTR6 | P50406 | 1/20 | 0.90 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.63 |
| ▸ | AKT1 | P31749 | 4/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfadimethoxine SCHEMBL93845 | 0.95 | LMNA (1.00) | ALDH1A1LMNACYP3A4HTR6KMT2A | |
| Sulfadimethoxine SCHEMBL29363944 | 0.95 | LMNA (1.00) | ALDH1A1LMNACYP3A4HTR6KMT2A | |
| Sulfadimethoxine SCHEMBL2430279 | 0.94 | LMNA (0.97) | ALDH1A1LMNACYP3A4HTR6KMT2A | |
| Sulfadimethoxine SCHEMBL23928724 | 0.85 | ALDH1A1 (0.80) | ALDH1A1LMNACYP3A4HTR6KMT2A | |
| Sulfadimethoxine SCHEMBL17102809 | 0.85 | LMNA (0.80) | ALDH1A1LMNACYP3A4HTR6KMT2A | |
| Sulfadimethoxine SCHEMBL6006340 | 0.85 | ALDH1A1 (0.80) | ALDH1A1LMNACYP3A4HTR6KMT2A | |
| Sulfadimethoxine SCHEMBL28086139 | 0.83 | ALDH1A1 (0.77) | ALDH1A1LMNACYP3A4HTR6KMT2A | |
| SCHEMBL7824834 | 0.83 | ALDH1A1 (0.78) | ALDH1A1LMNACYP3A4HTR6KMT2A | |
| SCHEMBL7837632 | 0.83 | HTR6 (0.78) | ALDH1A1LMNACYP3A4HTR6KMT2A | |
| Sulfadimethoxine SCHEMBL13372563 | 0.82 | ALDH1A1 (0.76) | ALDH1A1LMNACYP3A4HTR6KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103717597-B | Heterocyclic compounds as kinase inhibitors | 原真股份有限公司 | 2017-07-04 | — | — | CN | disclosed |
| EP-0523529-A2 | Anticoccidial compositions | F. HOFFMANN-LA ROCHE AG (CH) | 1993-01-20 | — | — | EP | disclosed |