Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | CHUK | O15111 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 6/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 6/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.33 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL999957 | 0.89 | KIF11 (0.38) | KIF11MAPTESR1ROCK2CHUK | |
| SCHEMBL998662 | 0.85 | KIF11 (0.39) | KIF11MAPTESR1ROCK2TP53 | |
| SCHEMBL998181 | 0.84 | KIF11 (0.42) | KIF11MAPTESR1ABCB1ABCG2 | |
| SCHEMBL998567 | 0.82 | KIF11 (0.40) | KIF11MAPTESR1ABCB1ABCG2 | |
| SCHEMBL997862 | 0.78 | KIF11 (0.41) | KIF11MAPTESR1TP53CYP2D6 | |
| SCHEMBL997430 | 0.76 | KIF11 (0.61) | KIF11MAPTABCB1ABCG2TP53 | |
| SCHEMBL997542 | 0.76 | KIF11 (0.38) | KIF11MAPTESR1TP53LMNA | |
| SCHEMBL1000700 | 0.74 | KIF11 (0.53) | KIF11MAPTABCB1ABCG2TP53 | |
| SCHEMBL999207 | 0.74 | KIF11 (0.38) | KIF11ESR1CYP2D6 | |
| SCHEMBL1000704 | 0.74 | KIF11 (0.36) | KIF11MAPTESR1ABCB1ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1637521-A1 | NOVEL TRICYCLIC HETEROCYCLE COMPOUND | ONO PHARMACEUTICAL CO., LTD. (JP) | 2006-03-22 | — | — | EP | disclosed |