Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 3/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.36 |
| ▸ | CHUK | O15111 | 2/20 | 0.36 |
| ▸ | ICOSLG | O75144 | 2/20 | 0.36 |
| ▸ | ICOS | Q9Y6W8 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL998567 | 0.93 | KIF11 (0.40) | KIF11ABCB1ABCG2MAPTESR1 | |
| SCHEMBL6007489 | 0.89 | KIF11 (0.39) | KIF11ROCK2ABCB1ABCG2CHUK | |
| SCHEMBL1000704 | 0.86 | KIF11 (0.36) | KIF11ABCB1ABCG2MAPTESR1 | |
| SCHEMBL998702 | 0.85 | KIF11 (0.36) | KIF11ALDH1A1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL998662 | 0.85 | KIF11 (0.39) | KIF11ROCK2MAPTESR1ALDH1A1 | |
| SCHEMBL998302 | 0.84 | KIF11 (0.37) | KIF11ALDH1A1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL998800 | 0.83 | KIF11 (0.39) | KIF11ABCB1ABCG2ESR1ALDH1A1 | |
| SCHEMBL999387 | 0.83 | KIF11 (0.36) | KIF11ALDH1A1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL998181 | 0.83 | KIF11 (0.42) | KIF11ABCB1ABCG2MAPTESR1 | |
| SCHEMBL1000700 | 0.82 | KIF11 (0.53) | KIF11ABCB1ABCG2MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7872133-B2 | Tricyclic heterocycle compound | ONO PHARMACEUTICAL CO., LTD. (JP) | 2011-01-18 | — | — | US | disclosed |
| US-20060154944-A1 | Novel tricyclic heterocycle compound | ONO PHARMACEUTICAL CO., LTD. (JP) | 2006-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060154944-A1 | Novel tricyclic heterocycle compound | CYP11B1, CYP11B2, HCCS | KIF11 4760/4885ROCK2 4107/4885ABCB1 307/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.