Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 6/20 | 0.47 |
| ▸ | ADRA1D known ✓ | P25100 | 3/20 | 0.43 |
| ▸ | ADRA1A known ✓ | P35348 | 3/20 | 0.43 |
| ▸ | ADRA1B known ✓ | P35368 | 3/20 | 0.43 |
| ▸ | ADRA2A known ✓ | P08913 | 2/20 | 0.42 |
| ▸ | ADRA2B known ✓ | P18089 | 2/20 | 0.42 |
| ▸ | ADRA2C known ✓ | P18825 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 3/20 | 0.50 |
| ▸ | DRD1 | P21728 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 6/20 | 0.47 |
| ▸ | CA2 | P00918 | 6/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL7037393 | 0.83 | DRD2 (0.50) | DRD2DRD1CA1CA2ACHE | |
| SCHEMBL3829971 | 0.81 | DRD2 (0.51) | DRD2DRD1CA1CA2ACHE | |
| SCHEMBL6843823 | 0.81 | DRD2 (0.51) | DRD2DRD1CA1CA2ACHE | |
| Hydrochloric Acid SCHEMBL6547743 | 0.80 | DRD2 (0.50) | DRD2DRD1CA1CA2ACHE | |
| SCHEMBL2956868 | 0.79 | ADRA1D (0.49) | DRD2DRD1CA1CA2ACHE | |
| SCHEMBL11520474 | 0.78 | DRD2 (0.57) | DRD2DRD1CA1CA2ACHE | |
| Bromide SCHEMBL7336396 | 0.77 | DRD2 (0.69) | DRD2DRD1ADRA1DADRA1AADRA1B | |
| Bromide SCHEMBL7336392 | 0.77 | DRD2 (0.69) | DRD2DRD1ADRA1DADRA1AADRA1B | |
| Bromide SCHEMBL7204012 | 0.77 | DRD2 (0.65) | DRD2DRD1DRD4DRD3 | |
| Bromide SCHEMBL7271594 | 0.75 | ADRA1D (0.63) | DRD2DRD1ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7132441-B2 | Immunosuppressive effects of administration of a cyclooxygenase-2 inhibitor and a 5-lipoxygenase inhibitor | G.D. SEARLE & CO. (US) | 2006-11-07 | — | — | US | disclosed |