Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SCN4A | P35499 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL794717 | 0.86 | DRD4 (0.43) | PTGS2DRD2DRD4DRD3MAOB | |
| SCHEMBL10944086 | 0.84 | FFAR1 (0.41) | PTGS2ALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL11384928 | 0.83 | ALDH1A3 (0.49) | ALDH1A1MEN1KMT2ARAB9AL3MBTL1 | |
| SCHEMBL12696325 | 0.77 | TYR (0.47) | ALDH1A1MEN1KMT2ARAB9AL3MBTL1 | |
| SCHEMBL2726596 | 0.75 | CA12 (0.42) | ALDH1A1RAB9AL3MBTL1HPGD | |
| SCHEMBL1951879 | 0.74 | ALDH1A1 (0.52) | ALDH1A1DRD2DRD4DRD3MAOB | |
| SCHEMBL28456471 | 0.74 | MEN1 (0.39) | PTGS2ALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL2081426 | 0.73 | HSD17B10 (0.64) | ALDH1A1L3MBTL1HPGD | |
| SCHEMBL19692522 | 0.72 | CYP1A2 (0.44) | PTGS2ALDH1A1MEN1KMT2ADRD2 | |
| SCHEMBL5648390 | 0.72 | PPARG (0.44) | ALDH1A1RAB9ANPC1MAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1445251-B1 | Aminoacetonitrile derivative, agricultural and horticultural insecticide containing the same, and use thereof | NIHON NOHYAKU CO LTD (JP) | 2006-12-27 | — | — | EP | disclosed |
| EP-1445251-A9 | Aminoacetonitrile derivative, agricultural and horticultural insecticide containing the same, and use thereof | NIHON NOHYAKU CO., LTD. (JP) | 2004-11-03 | — | — | EP | disclosed |
| EP-0953565-B1 | Aminoacetonitrile derivative, agricultural and horticultural insecticide containing the same, and use thereof | NIHON NOHYAKU CO LTD (JP) | 2004-09-08 | — | — | EP | disclosed |
| EP-1445251-A1 | Aminoacetonitrile derivative, agricultural and horticultural insecticitde containing the same, and use thereof | NIHON NOHYAKU CO., LTD. (JP) | 2004-08-11 | — | — | EP | disclosed |
| US-20040009976-A1 | Hypoglycemic imidazoline compounds | TAKEUCHI KUMIKO (US) | 2004-01-15 | — | — | US | disclosed |
| EP-0924209-B1 | Hypoglycemic imidazoline compounds | LILLY CO ELI (US) | 2003-05-02 | — | — | EP | disclosed |
| EP-1266897-A2 | Hypoglycemic imidazoline compounds | ELI LILLY AND COMPANY (US) | 2002-12-18 | — | — | EP | disclosed |
| US-6410562-B1 | ANTIDIABETIC AGENTS | ELI LILLY AND COMPANY | 2002-06-25 | — | — | US | disclosed |
| US-6239077-B1 | PESTICIDES; APPLYING TO PLANTS | NIHON NOHYAKU CO., LTD. (JP) | 2001-05-29 | — | — | US | disclosed |
| EP-0953565-A2 | Aminoacetonitrile derivative, agricultural and horticultural insecticide containing the same, and use thereof | NIHON NOHYAKU CO., LTD. (JP) | 1999-11-03 | — | — | EP | disclosed |
| WO-1999032482-A1 | HYPOGLYCEMIC IMIDAZOLINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 1999-07-01 | — | — | WO | disclosed |
| EP-0924209-A1 | Hypoglycemic imidazoline compounds | ELI LILLY AND COMPANY (US) | 1999-06-23 | — | — | EP | disclosed |
| US-4511575-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4511576-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4351843-A | LOWERING BLOOD GLUCOSE | PFIZER INC. (US) | 1982-09-28 | — | — | US | disclosed |
| US-4282242-A | HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1981-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040009976-A1 | Hypoglycemic imidazoline compounds | GPR119, IAPP, GLP1R | PTGS2 3400/4885ALDH1A1 1932/4885MEN1 3139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.