Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 5/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 5/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.32 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.31 |
| ▸ | ESRRG | P62508 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL5025873 | 0.94 | AR (0.39) | ARKDM4EALDH1A1POLBGAA | |
| Iodide SCHEMBL5028676 | 0.94 | AR (0.37) | ARKDM4EALDH1A1GAAESRRG | |
| Iodide SCHEMBL5027296 | 0.93 | AR (0.36) | ARKDM4EALDH1A1POLBGAA | |
| Iodide SCHEMBL5027441 | 0.91 | PTPN11 (0.36) | ARKDM4EALDH1A1POLBGAA | |
| Iodide SCHEMBL6014674 | 0.84 | SLC16A3 (0.39) | ARALDH1A1NR1H2NR1H3SLC16A3 | |
| Iodide SCHEMBL6014586 | 0.84 | SLC16A3 (0.39) | ARALDH1A1NR1H2NR1H3SLC16A3 | |
| Iodide SCHEMBL5027491 | 0.81 | ALDH1A1 (0.43) | ARKDM4EALDH1A1GAAEGFR | |
| SCHEMBL1472499 | 0.78 | SNCA (0.39) | ARKDM4EALDH1A1POLBGAA | |
| SCHEMBL11763196 | 0.74 | SNCA (0.41) | ARKDM4EALDH1A1POLBGAA | |
| SCHEMBL1472475 | 0.73 | SNCA (0.38) | ARKDM4EALDH1A1POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006032848-A1 | PHOTOSENSITISERS AND THEIR USES | PHOTOPHARMICA LIMITED (GB) | 2006-03-30 | — | — | WO | disclosed |