Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | CASP1 | P29466 | 2/20 | 0.43 |
| ▸ | CASP7 | P55210 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TERT | O14746 | 1/20 | 0.42 |
| ▸ | S100B | P04271 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL5028676 | 0.86 | AR (0.37) | ALDH1A1MAPTHSD17B10LMNATDP1 | |
| Iodide SCHEMBL5027296 | 0.82 | AR (0.36) | ALDH1A1TDP1KDM4EGAABCHE | |
| Iodide SCHEMBL5027441 | 0.81 | PTPN11 (0.36) | ALDH1A1TDP1KDM4EGAACNR2 | |
| Iodide SCHEMBL6014579 | 0.81 | AR (0.38) | ALDH1A1KDM4EGAABCHEACHE | |
| Bromide SCHEMBL5025873 | 0.80 | AR (0.39) | ALDH1A1KDM4EGAABCHEACHE | |
| SCHEMBL29822211 | 0.74 | IDO1 (0.33) | ALDH1A1MAPTHSD17B10LMNATDP1 | |
| Hydrochloric Acid SCHEMBL498310 | 0.73 | KDM4E (0.33) | ALDH1A1MAPTHSD17B10LMNATDP1 | |
| SCHEMBL972682 | 0.73 | SNCA (0.46) | ALDH1A1MAPTHSD17B10LMNATDP1 | |
| SCHEMBL80727 | 0.73 | ALDH1A1 (0.44) | ALDH1A1MAPTHSD17B10LMNATDP1 | |
| SCHEMBL29895860 | 0.73 | ALDH1A1 (0.44) | ALDH1A1MAPTHSD17B10LMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7407948-B2 | Photosensitisers and their uses | PHOTOPHARMICA LIMITED (GB) | 2008-08-05 | — | — | US | disclosed |
| US-20070197494-A1 | Photosensitisers and their uses | PHOTOPHARMICA LIMITED (GB) | 2007-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197494-A1 | Photosensitisers and their uses | CRY1, CYP4Z1, QDPR | ACHE 621/4885ALDH1A1 1383/4885MAPT 2322/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.