Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 2/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.34 |
| ▸ | PTPRO | Q16827 | 1/20 | 0.34 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.34 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 2/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL5027441 | 0.98 | PTPN11 (0.36) | ARPTPN11PTPROSLC16A3SLC16A1 | |
| Iodide SCHEMBL6014579 | 0.93 | AR (0.38) | ARSLC16A3SLC16A1KDM4EALDH1A1 | |
| Bromide SCHEMBL5025873 | 0.92 | AR (0.39) | ARSLC16A3SLC16A1KDM4EALDH1A1 | |
| Iodide SCHEMBL5028676 | 0.89 | AR (0.37) | ARKDM4EALDH1A1GAATDP1 | |
| Iodide SCHEMBL5027491 | 0.82 | ALDH1A1 (0.43) | ARKDM4EALDH1A1GAACNR2 | |
| SCHEMBL3898904 | 0.81 | AR (0.39) | ARPTPN11PTPROSLC16A3SLC16A1 | |
| Iodide SCHEMBL6014586 | 0.78 | SLC16A3 (0.39) | ARSLC16A3SLC16A1ALDH1A1 | |
| Iodide SCHEMBL6014674 | 0.78 | SLC16A3 (0.39) | ARSLC16A3SLC16A1ALDH1A1 | |
| SCHEMBL1472458 | 0.76 | SNCA (0.39) | ARPTPN11PTPROSLC16A3SLC16A1 | |
| SCHEMBL1472475 | 0.75 | SNCA (0.38) | ARPTPN11PTPROSLC16A3SLC16A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7407948-B2 | Photosensitisers and their uses | PHOTOPHARMICA LIMITED (GB) | 2008-08-05 | — | — | US | disclosed |
| US-20070197494-A1 | Photosensitisers and their uses | PHOTOPHARMICA LIMITED (GB) | 2007-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197494-A1 | Photosensitisers and their uses | CRY1, CYP4Z1, QDPR | ACHE 621/4885AR 3912/4885PTPN11 1770/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.