Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 15/20 | 1.00 |
| ▸ | RAB9A | P51151 | 15/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 14/20 | 1.00 |
| ▸ | MAPT | P10636 | 12/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.65 |
| ▸ | MEN1 | O00255 | 4/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | HTT | P42858 | 4/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.54 |
| ▸ | RELA | Q04206 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6015577 | 0.84 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL6015594 | 0.78 | MAPT (1.00) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL6015586 | 0.75 | MAPT (0.62) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL6015581 | 0.73 | RAB9A (0.58) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL5510570 | 0.72 | MAPT (0.62) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL10533789 | 0.72 | NPC1 (0.66) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL18079703 | 0.71 | RAB9A (1.00) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL6840443 | 0.70 | CYP1A2 (0.59) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL31211649 | 0.70 | CYP1A2 (0.59) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL1379965 | 0.70 | RAB9A (0.60) | NPC1RAB9ASMN1; SMN2MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012054526-A2 | CHEMOSENSORY RECEPTOR LIGAND-BASED THERAPIES | ELCELYX THERAPEUTICS, INC. (US) | 2012-04-26 | — | — | WO | disclosed |