Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | HTR1B | P28222 | 2/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22510178 | 0.81 | HRH3 (0.55) | HRH3CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL6015805 | 0.78 | LTA4H (0.56) | HRH3 | |
| SCHEMBL6015872 | 0.77 | LTA4H (0.55) | HRH3 | |
| SCHEMBL6016063 | 0.77 | LTA4H (0.55) | HRH3 | |
| SCHEMBL14578202 | 0.76 | CHRNB4 (0.65) | HRH3CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL6016024 | 0.74 | MAOA (0.36) | HTR1AHTR1B | |
| SCHEMBL14577979 | 0.74 | SLC2A1 (0.53) | HRH3CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL11448416 | 0.74 | LMNA (0.58) | HRH3CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL11450541 | 0.73 | SLC2A1 (0.50) | HRH3CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL14578201 | 0.73 | CHRNB4 (0.62) | HRH3CHRNB4CHRNA3CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7049312-B1 | Benzothiazinone and benzoxazinone compounds | ABBOTT GMBH & CO. KG (DE) | 2006-05-23 | — | — | US | claimed |
| EP-1181282-A2 | BENZOTHIAZINONE AND BENZOXAZINONE COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2002-02-27 | — | — | EP | claimed |
| WO-2000075139-A2 | BENZOTHIAZINONE AND BENZOXAZINONE COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2000-12-14 | — | — | WO | claimed |
| US-7049312-B1 | Benzothiazinone and benzoxazinone compounds | ABBOTT GMBH & CO. KG (DE) | 2006-05-23 | — | — | US | disclosed |