Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.51 |
| ▸ | PSMB1 | P20618 | 5/20 | 0.50 |
| ▸ | PSMB5 | P28074 | 5/20 | 0.50 |
| ▸ | PSMB2 | P49721 | 4/20 | 0.50 |
| ▸ | BACE1 | P56817 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6016063 | 1.00 | LTA4H (0.55) | LTA4HHRH3PSMB1PSMB5PSMB2 | |
| SCHEMBL6015805 | 0.99 | LTA4H (0.56) | LTA4HHRH3PSMB1PSMB5PSMB2 | |
| SCHEMBL6015732 | 0.90 | LTA4H (0.59) | LTA4HHRH3PSMB1PSMB5PSMB2 | |
| SCHEMBL6015916 | 0.88 | LTA4H (0.60) | LTA4HHRH3PSMB1PSMB5PSMB2 | |
| SCHEMBL6016018 | 0.87 | KDM4E (0.55) | LTA4HHRH3KDM4EKMT2A | |
| SCHEMBL6015785 | 0.77 | ALDH1A1 (0.55) | LTA4HHRH3KDM4EKMT2A | |
| SCHEMBL6015740 | 0.77 | HRH3 (0.47) | HRH3 | |
| SCHEMBL17384760 | 0.76 | LTA4H (0.84) | LTA4HHRH3PSMB1PSMB5PSMB2 | |
| SCHEMBL1797351 | 0.76 | PARP1 (0.62) | LTA4HHRH3PSMB1PSMB5PSMB2 | |
| SCHEMBL6015874 | 0.76 | MAOA (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7049312-B1 | Benzothiazinone and benzoxazinone compounds | ABBOTT GMBH & CO. KG (DE) | 2006-05-23 | — | — | US | claimed |
| EP-1181282-A2 | BENZOTHIAZINONE AND BENZOXAZINONE COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2002-02-27 | — | — | EP | claimed |
| WO-2000075139-A2 | BENZOTHIAZINONE AND BENZOXAZINONE COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2000-12-14 | — | — | WO | claimed |
| US-7049312-B1 | Benzothiazinone and benzoxazinone compounds | ABBOTT GMBH & CO. KG (DE) | 2006-05-23 | — | — | US | disclosed |