Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | PARP1 | P09874 | 2/20 | 0.58 |
| ▸ | CD274 | Q9NZQ7 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.57 |
| ▸ | MAOA | P21397 | 1/20 | 0.57 |
| ▸ | MAOB | P27338 | 1/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6015966 | 0.90 | HTR3A (0.54) | POLBCYP1A2CYP2D6PARP1ALDH1A1 | |
| SCHEMBL6015678 | 0.89 | HTR3A (0.56) | POLBCYP1A2CYP2D6PARP1ALDH1A1 | |
| SCHEMBL6015856 | 0.81 | RAD52 (0.54) | CYP2D6ALDH1A1HPGDKDM4ECYP2C9 | |
| SCHEMBL3536679 | 0.81 | CYP2C19 (0.69) | POLBCYP2C19CYP1A2CYP2D6PARP1 | |
| SCHEMBL6016002 | 0.80 | ATM (0.58) | CYP1A2ALDH1A1HPGDKDM4E | |
| SCHEMBL30265188 | 0.78 | POLB (0.60) | POLBCYP2C19CYP1A2CYP2D6PARP1 | |
| SCHEMBL6016009 | 0.77 | TNKS2 (0.47) | POLBCYP2C19CYP1A2CYP2D6PARP1 | |
| SCHEMBL6015635 | 0.76 | BCL3 (0.56) | CD274ALDH1A1HPGD | |
| SCHEMBL6015810 | 0.76 | ALDH1A1 (0.60) | POLBCYP2C19CYP2D6ALDH1A1 | |
| SCHEMBL2350430 | 0.76 | POLB (0.60) | POLBCYP2C19CYP1A2CYP2D6PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7049312-B1 | Benzothiazinone and benzoxazinone compounds | ABBOTT GMBH & CO. KG (DE) | 2006-05-23 | — | — | US | claimed |
| US-7049312-B1 | Benzothiazinone and benzoxazinone compounds | ABBOTT GMBH & CO. KG (DE) | 2006-05-23 | — | — | US | disclosed |
| EP-1181282-A2 | BENZOTHIAZINONE AND BENZOXAZINONE COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2002-02-27 | — | — | EP | disclosed |
| WO-2000075139-A2 | BENZOTHIAZINONE AND BENZOXAZINONE COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2000-12-14 | — | — | WO | disclosed |