Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A known ✓ | P35498 | 1/20 | 0.40 |
| ▸ | SCN2A known ✓ | Q99250 | 1/20 | 0.40 |
| ▸ | SCN3A known ✓ | Q9NY46 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 10/20 | 0.64 |
| ▸ | ADORA2A | P29274 | 7/20 | 0.64 |
| ▸ | ADORA3 | P0DMS8 | 7/20 | 0.64 |
| ▸ | PDE4A | P27815 | 5/20 | 0.64 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.64 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.64 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.64 |
| ▸ | PDE2A | O00408 | 4/20 | 0.51 |
| ▸ | PDE1A | P54750 | 2/20 | 0.51 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.51 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.51 |
| ▸ | CFTR | P13569 | 2/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL59949 | 0.94 | ADORA2B (0.72) | ADORA2BADORA2AADORA3PDE4APDE4B | |
| Xanthine SCHEMBL692608 | 0.85 | ADORA2B (0.61) | ADORA2BADORA2AADORA3PDE4APDE4B | |
| SCHEMBL5451521 | 0.80 | ADORA2B (0.68) | ADORA2BADORA2AADORA3PDE4APDE4B | |
| SCHEMBL60158 | 0.80 | ADORA2A (0.70) | ADORA2BADORA2AADORA3PDE4APDE4B | |
| SCHEMBL4602969 | 0.78 | ADORA2B (0.73) | ADORA2BADORA2AADORA3PDE4APDE4B | |
| SCHEMBL4423680 | 0.78 | ADORA2B (1.00) | ADORA2BADORA2AADORA3PDE4APDE4B | |
| SCHEMBL7326960 | 0.78 | ADORA2A (0.67) | ADORA2BADORA2AADORA3PDE4APDE4B | |
| SCHEMBL27256851 | 0.78 | ADORA2B (0.68) | ADORA2BADORA2AADORA3PDE4APDE4B | |
| SCHEMBL6233166 | 0.76 | ADORA2B (1.00) | ADORA2BADORA2AADORA3PDE4APDE4B | |
| SCHEMBL31081359 | 0.76 | ADORA2B (0.74) | ADORA2BADORA2AADORA3PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999032605-A1 | METHOD FOR PRODUCING HETEROLOGOUS PROTEINS IN EUKARYOTIC CELLS ON AN INDUSTRIAL SCALE USING NUCLEOTIDE-MANIPULATING AGENTS | NOVO NORDISK A/S (DK) | 1999-07-01 | — | — | WO | disclosed |