Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10856486 | 0.78 | MEN1 (0.70) | MEN1KMT2AHSD17B10SMN1; SMN2NPC1 | |
| SCHEMBL6015763 | 0.78 | MEN1 (0.61) | MEN1KMT2ASMN1; SMN2NPC1TSHR | |
| SCHEMBL11010135 | 0.78 | MEN1 (0.69) | MEN1KMT2AHSD17B10SMN1; SMN2NPC1 | |
| SCHEMBL14552522 | 0.78 | MEN1 (0.69) | MEN1KMT2AHSD17B10SMN1; SMN2NPC1 | |
| SCHEMBL12323976 | 0.77 | MEN1 (0.69) | MEN1KMT2AHSD17B10SMN1; SMN2NPC1 | |
| SCHEMBL10655218 | 0.77 | MEN1 (0.69) | MEN1KMT2AHSD17B10SMN1; SMN2NPC1 | |
| SCHEMBL14552420 | 0.77 | MEN1 (0.83) | MEN1KMT2AHSD17B10SMN1; SMN2NPC1 | |
| SCHEMBL6015695 | 0.76 | DRD2 (0.47) | KMT2AHSD17B10SMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL14552369 | 0.76 | MEN1 (0.67) | MEN1KMT2AHSD17B10SMN1; SMN2NPC1 | |
| SCHEMBL14552392 | 0.75 | MEN1 (0.66) | MEN1KMT2AHSD17B10SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7049312-B1 | Benzothiazinone and benzoxazinone compounds | ABBOTT GMBH & CO. KG (DE) | 2006-05-23 | — | — | US | claimed |
| US-7049312-B1 | Benzothiazinone and benzoxazinone compounds | ABBOTT GMBH & CO. KG (DE) | 2006-05-23 | — | — | US | disclosed |
| EP-1181282-A2 | BENZOTHIAZINONE AND BENZOXAZINONE COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2002-02-27 | — | — | EP | disclosed |
| WO-2000075139-A2 | BENZOTHIAZINONE AND BENZOXAZINONE COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2000-12-14 | — | — | WO | disclosed |