Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LGALS1 | P09382 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | HBB | P68871 | 1/20 | 0.35 |
| ▸ | PAICS | P22234 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2103703 | 0.75 | KDM4E (0.49) | KDM4EUSP2MAPK1ALDH1A1LMNA | |
| SCHEMBL1557765 | 0.72 | KDM4E (0.41) | KDM4EUSP2MAPK1ALDH1A1LMNA | |
| SCHEMBL6015745 | 0.72 | KDM4E (0.46) | KDM4EUSP2MAPK1ALDH1A1LMNA | |
| Water SCHEMBL9877241 | 0.67 | LMNA (0.51) | KDM4EUSP2MAPK1ALDH1A1LMNA | |
| SCHEMBL31459289 | 0.65 | ALDH1A1 (0.45) | KDM4EUSP2MAPK1ALDH1A1LMNA | |
| SCHEMBL1557707 | 0.65 | DNM1 (0.43) | KDM4EALDH1A1DNM1MAPT | |
| SCHEMBL13584322 | 0.63 | DNM1 (0.57) | USP2MAPK1ALDH1A1NPSR1CYP2D6 | |
| SCHEMBL31537579 | 0.63 | ALDH1A1 (0.47) | KDM4EUSP2MAPK1ALDH1A1LMNA | |
| SCHEMBL4280071 | 0.62 | ALDH1A1 (0.70) | KDM4EUSP2MAPK1ALDH1A1DNM1 | |
| SCHEMBL47678 | 0.62 | DNM1 (0.60) | USP2MAPK1ALDH1A1NPSR1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1181282-A2 | BENZOTHIAZINONE AND BENZOXAZINONE COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2002-02-27 | — | — | EP | claimed |
| WO-2000075139-A2 | BENZOTHIAZINONE AND BENZOXAZINONE COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2000-12-14 | — | — | WO | claimed |
| US-7049312-B1 | Benzothiazinone and benzoxazinone compounds | ABBOTT GMBH & CO. KG (DE) | 2006-05-23 | — | — | US | disclosed |