Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | SCN1A | P35498 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17008888 | 0.69 | SMN1; SMN2 (0.46) | SMN1; SMN2LMNAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL14553277 | 0.68 | ALDH1A1 (0.51) | SMN1; SMN2LMNAALDH1A1MAPK1CYP1A2 | |
| SCHEMBL6016059 | 0.67 | MAPK1 (0.40) | SMN1; SMN2LMNAALDH1A1MAPK1USP2 | |
| SCHEMBL6015711 | 0.67 | LMNA (0.38) | LMNAALDH1A1MAPK1MAPTCYP1A2 | |
| SCHEMBL235080 | 0.66 | KDM4E (0.65) | SMN1; SMN2ALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL4964631 | 0.66 | SMN1; SMN2 (0.46) | SMN1; SMN2LMNAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL4961612 | 0.66 | SMN1; SMN2 (0.46) | SMN1; SMN2LMNAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL13433946 | 0.66 | NPC1 (0.56) | SMN1; SMN2LMNAALDH1A1KDM4EMAPK1 | |
| SCHEMBL8629624 | 0.64 | SMN1; SMN2 (0.39) | SMN1; SMN2LMNAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL16254583 | 0.64 | KDM5A (0.49) | SMN1; SMN2LMNAALDH1A1MAPK1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7049312-B1 | Benzothiazinone and benzoxazinone compounds | ABBOTT GMBH & CO. KG (DE) | 2006-05-23 | — | — | US | claimed |
| EP-1181282-A2 | BENZOTHIAZINONE AND BENZOXAZINONE COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2002-02-27 | — | — | EP | claimed |
| WO-2000075139-A2 | BENZOTHIAZINONE AND BENZOXAZINONE COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2000-12-14 | — | — | WO | claimed |
| US-7049312-B1 | Benzothiazinone and benzoxazinone compounds | ABBOTT GMBH & CO. KG (DE) | 2006-05-23 | — | — | US | disclosed |