SCHEMBL60159

SCHEMBL60159

CC(C)Cc1nc2[nH]c(=O)[nH]c(=O)c2[nH]1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.46
MAPT P10636 3/20 0.44
ADORA2B P29275 2/20 0.41
XDH P47989 3/20 0.39
GSK3B P49841 1/20 0.37
GDA Q9Y2T3 2/20 0.37
ACHE P22303 1/20 0.37
ADORA3 P0DMS8 1/20 0.35
ADORA2A P29274 1/20 0.35
ADORA1 P30542 1/20 0.35
ALDH1A1 P00352 2/20 0.34
HSD17B10 Q99714 2/20 0.34
CYP3A4 P08684 1/20 0.34
HPGD P15428 1/20 0.34
ALOX15 P16050 1/20 0.34
MAPK1 P28482 1/20 0.34
KDM4E B2RXH2 2/20 0.33
ENPP1 P22413 1/20 0.32
CCNE2 O96020 1/20 0.32
CCNE1 P24864 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7326964 0.87 MAPT (0.42) TSHRMAPTADORA2BXDHGDA
SCHEMBL3489066 0.85 HCAR2 (0.42) TSHRMAPTADORA2BXDHGDA
SCHEMBL541696 0.83 MAPT (0.42) TSHRMAPTADORA2BXDHGDA
SCHEMBL380136 0.80 MAPT (0.48) MAPTADORA2BXDHGDAACHE
SCHEMBL1111557 0.79 MAPT (0.36) MAPTADORA2BXDHGDAACHE
SCHEMBL4014478 0.78 MAPT (0.40) MAPTADORA2BXDHGDAACHE
SCHEMBL1150739 0.77 XDH (0.47) MAPTADORA2BXDHGDAACHE
SCHEMBL31438586 0.77 MAPT (0.48) MAPTADORA2BXDHGDAACHE
SCHEMBL5515639 0.77 ADORA2B (0.49) MAPTADORA2BXDHGDAACHE
SCHEMBL3399435 0.77 MAPT (0.48) MAPTADORA2BXDHGDAACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 215 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2446024-A1 MESENCHYMAL STEM CELLS GROWN UNDER HYPOXIC CONDITIONS: COMPOSITIONS, METHODS AND USES THEREFOR Life&Light Limited (GB) 2012-05-02 EP claimed
US-20100330047-A1 Mesenchymal Stem Cells Grown Under Hypoxic Conditions: Compositions, Methods and Uses Therefor LIFE & LIGHT LTD. (GB) 2010-12-30 US claimed
WO-2010150094-A1 MESENCHYMAL STEM CELLS GROWN UNDER HYPOXIC CONDITIONS: COMPOSITIONS, METHODS AND USES THEREFOR LIFE & LIGHT LIMITED (GB) 2010-12-29 WO claimed
WO-2010108008-A2 BSC CELL DIFFERENTIATION AND USE IN THERAPY UNIVERSITY OF GEORGIA RESEARCH FOUNDATION (US) 2010-09-23 WO claimed
CN-1134537-C Separation, extracorporeal culture, preparation and application of human primitive mesenchymal stem cell population 四川轻化工学院 2004-01-14 CN claimed
CN-1287166-A Separation, extracorporeal culture, preparation and application of human primitive mesenchymal stem cell population HE QINGHUA (CN) 2001-03-14 CN claimed
US-12173323-B2 Methods of using PDX1-positive pancreatic endoderm cells and endocrine precursor cells VIACYTE, INC. (US) 2024-12-24 US disclosed
US-20240409900-A1 CELL ENCAPSULATION DEVICE COMPRISING A PANCREATIC PROGENITOR CELL POPULATION VIACYTE, INC. (US) 2024-12-12 US disclosed
US-20240220740-A1 AUTOMATIC CONSTRUCTION METHOD FOR PARALLEL CORPORA AND INFORMATION PROCESSING APPARATUS FUJITSU LIMITED (JP) 2024-07-04 US disclosed
EP-4394648-A1 PARALLEL CORPUS CONSTRUCTION PROGRAM, PARALLEL CORPUS CONSTRUCTION METHOD, AND INFORMATION PROCESSING APPARATUS FUJITSU LIMITED (JP) 2024-07-03 EP disclosed
US-11905530-B2 Cell encapsulation device comprising a pancreatic progenitor cell population VIACYTE, INC. (US) 2024-02-20 US disclosed
US-11896622-B2 Methods of producing pancreatic hormones VIACYTE, INC. (US) 2024-02-13 US disclosed
US-20230285296-A1 LAYER-BY-LAYER COATED NANOLIPOSOME FOR ORAL DELIVERY OF INSULIN NANYANG TECHNOLOGICAL UNIVERSITY (SG) 2023-09-14 US disclosed
CN-1206420-A Novel A1 adenosine receptor agonists and antagonists UNIV FLORIDA (US) 1999-01-27 CN disclosed
CN-1182432-A Human neuropeptide receptor HUMAN GENOME SCIENCES INC (US) 1998-05-20 CN disclosed
US-5480999-A CONTAINING AN ACID AND AN ARGININE ANALOGUE SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) 1996-01-02 US disclosed
US-5360925-A Cardio cerebrovascular disorders, antiinflammatory agents and immune disorders SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (FR) 1994-11-01 US disclosed
EP-0116938-A1 Benzoheterocyclic carbamates USV PHARMACEUTICAL CORPORATION (US) 1984-08-29 EP disclosed
US-4456687-A CULTURES; CYCLIC ADENOSINE-3'-PHOSPHATE STIMULANTS PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 1984-06-26 US disclosed
US-4435404-A ANTICOAGULANTS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1984-03-06 US disclosed