Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHPS | P49366 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 4/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.34 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6016955 | 0.89 | DHPS (0.42) | DHPSSMN1; SMN2MAPTLMNAL3MBTL1 | |
| SCHEMBL27634980 | 0.88 | DHPS (0.36) | DHPSSMN1; SMN2MAPTLMNAL3MBTL1 | |
| SCHEMBL1652155 | 0.79 | TBXA2R (0.51) | SMN1; SMN2MAPTLMNAL3MBTL1ALDH1A1 | |
| SCHEMBL27856649 | 0.78 | TBXA2R (0.50) | SMN1; SMN2MAPTLMNAHTTTP53 | |
| SCHEMBL27634902 | 0.78 | POLB (0.44) | SMN1; SMN2MAPTALDH1A1TP53TBXA2R | |
| SCHEMBL3442754 | 0.77 | PTGDR2 (0.50) | DHPSSMN1; SMN2MAPTLMNAL3MBTL1 | |
| SCHEMBL6878036 | 0.77 | PTGDR2 (0.65) | TBXA2RPTGDRPTGDR2 | |
| SCHEMBL12568718 | 0.77 | TBXA2R (0.41) | DHPSSMN1; SMN2MAPTLMNAL3MBTL1 | |
| SCHEMBL27655904 | 0.76 | TBXA2R (0.48) | SMN1; SMN2MAPTLMNAHTTTBXA2R | |
| SCHEMBL6016813 | 0.76 | EGFR (0.46) | PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633726-A1 | PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES MEDIATED BY CRTH2 | Actimis Pharmaceuticals, Inc., (US) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004096777-A1 | PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES MEDIATED BY CRTH2 | ACTIMIS PHARMACEUTICALS, INC. (US) | 2004-11-11 | — | — | WO | disclosed |