Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHPS | P49366 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | PRNP | P04156 | 3/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.34 |
| ▸ | CFD | P00746 | 1/20 | 0.33 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6016956 | 0.89 | DHPS (0.37) | DHPSNPSR1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL27634958 | 0.86 | DHPS (0.41) | DHPSNPSR1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL2791412 | 0.81 | CYP2C19 (0.43) | SMN1; SMN2KDM4ELMNATSHRALDH1A1 | |
| SCHEMBL27634980 | 0.76 | DHPS (0.36) | DHPSNPSR1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL12568934 | 0.75 | NPSR1 (0.45) | DHPSNPSR1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL4333030 | 0.75 | KMT2A (0.34) | NPSR1SMN1; SMN2KDM4EHPGDRXFP1 | |
| SCHEMBL3443252 | 0.74 | NPSR1 (0.40) | DHPSNPSR1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL1009043 | 0.73 | COPS5 (0.40) | DHPSNPSR1LMNATSHRALDH1A1 | |
| SCHEMBL12568718 | 0.69 | TBXA2R (0.41) | DHPSNPSR1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL3442754 | 0.69 | PTGDR2 (0.50) | DHPSNPSR1SMN1; SMN2KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633726-A1 | PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES MEDIATED BY CRTH2 | Actimis Pharmaceuticals, Inc., (US) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004096777-A1 | PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES MEDIATED BY CRTH2 | ACTIMIS PHARMACEUTICALS, INC. (US) | 2004-11-11 | — | — | WO | disclosed |