Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.50 |
| ▸ | ARHGDIA | P52565 | 2/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CCR3 | P51677 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3527134 | 0.85 | ROCK2 (0.59) | MEN1KMT2AOPRM1OPRK1KCNH2 | |
| SCHEMBL6017229 | 0.83 | KCNH2 (0.60) | MEN1KMT2AOPRM1OPRK1KCNH2 | |
| SCHEMBL7240972 | 0.81 | MAPK1 (0.54) | MEN1KMT2AOPRM1OPRK1KCNH2 | |
| SCHEMBL7240975 | 0.81 | MAPK1 (0.54) | MEN1KMT2AOPRM1OPRK1KCNH2 | |
| SCHEMBL3291604 | 0.81 | KDM4E (0.64) | ALDH1A1MAPTCCR3 | |
| SCHEMBL6758154 | 0.80 | LTA4H (0.65) | MEN1KMT2AOPRM1OPRK1KCNH2 | |
| SCHEMBL6758155 | 0.80 | LTA4H (0.65) | MEN1KMT2AOPRM1OPRK1KCNH2 | |
| SCHEMBL4019760 | 0.79 | ROCK2 (0.55) | MEN1KMT2AOPRM1OPRK1KCNH2 | |
| SCHEMBL4019763 | 0.79 | ROCK2 (0.55) | MEN1KMT2AOPRM1OPRK1KCNH2 | |
| SCHEMBL4435207 | 0.77 | KCNH2 (0.50) | MEN1KMT2AOPRM1OPRK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648888-A1 | N-(HETEROBICYCLOALKANES)-SUBSTITUTED INDOLES OR HETERODERIVATIVES THEREOF | Boehringer Ingelheim International GmbH (DE) | 2006-04-26 | — | — | EP | disclosed |
| US-20050014782-A1 | Novel n-(heterobicycloalkanes)-substituted indoles-or heteroderivatives thereof | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-01-20 | — | — | US | disclosed |
| WO-2005005425-A1 | N-(HETEROBICYCLOALKANES)-SUBTITUTED INDOLES- OR HETERODERIVATIVES THEREOF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-01-20 | — | — | WO | disclosed |
| EP-1496058-A1 | Novel N-(heterobicycloalkanes)-substituted Indoles or heteroderivatives thereof | Boehringer Ingelheim Pharma GmbH & Co.KG (DE) | 2005-01-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014782-A1 | Novel n-(heterobicycloalkanes)-substituted indoles-or heteroderivatives thereof | CCR3, CCR1, CCRL2 | MEN1 3345/4885KMT2A 4089/4885OPRM1 79/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.