Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 10/20 | 0.65 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.61 |
| ▸ | ARHGDIA | P52565 | 2/20 | 0.61 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.61 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.57 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.57 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
| ▸ | DRD2 | P14416 | 1/20 | 0.56 |
| ▸ | DRD4 | P21917 | 1/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.56 |
| ▸ | DRD3 | P35462 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6758155 | 1.00 | LTA4H (0.65) | LTA4HROCK2ARHGDIAROCK1OPRM1 | |
| SCHEMBL5595279 | 0.89 | LTA4H (0.54) | LTA4HROCK2ARHGDIAROCK1OPRM1 | |
| SCHEMBL14439615 | 0.89 | LTA4H (0.54) | LTA4HROCK2ARHGDIAROCK1OPRM1 | |
| SCHEMBL5595280 | 0.89 | LTA4H (0.54) | LTA4HROCK2ARHGDIAROCK1OPRM1 | |
| SCHEMBL6017233 | 0.80 | MEN1 (0.54) | LTA4HROCK2ARHGDIAROCK1OPRM1 | |
| SCHEMBL3872086 | 0.78 | SIGMAR1 (0.67) | OPRK1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL3997031 | 0.77 | ACHE (0.68) | LTA4HROCK2ROCK1ALDH1A1 | |
| SCHEMBL1974051 | 0.76 | ROCK2 (1.00) | ROCK2ARHGDIAROCK1 | |
| SCHEMBL12530366 | 0.76 | ALDH1A1 (0.62) | LTA4HOPRM1OPRD1OPRK1KCNH2 | |
| SCHEMBL31210789 | 0.76 | ALDH1A1 (0.58) | LTA4HROCK2ARHGDIAROCK1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040063688-A1 | Novel piperidine derivatives | PFIZER INC. | 2004-04-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063688-A1 | Novel piperidine derivatives | CCR1, CCR3, CCR2 | LTA4H 1151/4885ROCK2 2297/4885ARHGDIA 1265/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.