Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 5/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9923033 | 0.77 | OPRM1 (0.47) | OPRM1OPRD1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL9918374 | 0.76 | OPRM1 (0.46) | OPRM1OPRD1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL9899906 | 0.76 | NISCH (0.46) | OPRM1OPRD1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL817508 | 0.76 | ALDH1A1 (0.40) | OPRM1OPRD1KMT2APOLBKDM4E | |
| SCHEMBL3825964 | 0.72 | CHRNB2 (0.46) | OPRM1OPRD1KMT2AKDM4EALDH1A1 | |
| SCHEMBL15674662 | 0.69 | ALOX5 (0.39) | OPRM1OPRD1KMT2ASMN1; SMN2POLB | |
| SCHEMBL15674663 | 0.69 | ALOX5 (0.39) | OPRM1OPRD1KMT2ASMN1; SMN2POLB | |
| SCHEMBL18500255 | 0.69 | ALDH1A1 (0.38) | OPRM1OPRD1KMT2APOLBKDM4E | |
| Hydrochloric Acid SCHEMBL11203801 | 0.68 | CYP2A6 (0.42) | KMT2ASMN1; SMN2RAB9AKDM4EALDH1A1 | |
| SCHEMBL19801164 | 0.67 | NISCH (0.38) | OPRM1OPRD1KMT2AHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1709012-A1 | 6-SUBSTITUTED 2-QUINOLINONES AND 2-QUINOXALINONES AS POLY(ADP-RIBOSE)POLYMERASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005054210-A1 | 6-SUBSTITUTED 2-QUINOLINONES AND 2-QUINOXALINONES AS POLY(ADP-RIBOSE) POLYMERASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-06-16 | — | — | WO | disclosed |