Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 14/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6017485 | 0.85 | CHRM3 (0.37) | ALDH1A1MEN1MAPK1KMT2AKDM4E | |
| SCHEMBL2639275 | 0.84 | CHRM2 (0.45) | CHRM2ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL6017536 | 0.83 | HTR1A (0.36) | ALDH1A1MEN1MAPK1KMT2APOLB | |
| SCHEMBL6017518 | 0.82 | HTR1A (0.37) | CHRM2ALDH1A1MEN1MAPK1KMT2A | |
| SCHEMBL6021912 | 0.79 | CHRM2 (0.56) | CHRM2ALDH1A1KDM4E | |
| SCHEMBL6016864 | 0.77 | BCHE (0.37) | CHRM2ALDH1A1KDM4E | |
| SCHEMBL6022022 | 0.77 | CHRM2 (0.39) | CHRM2ALDH1A1KDM4ECHRM3 | |
| SCHEMBL6022322 | 0.77 | ADRB2 (0.35) | CHRM2ALDH1A1KDM4ECHRM3 | |
| SCHEMBL6022071 | 0.76 | GAA (0.46) | CHRM2ALDH1A1KDM4EPOLB | |
| SCHEMBL3726076 | 0.75 | CHRM3 (0.37) | CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1723113-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | Theravance, Inc. (US) | 2006-11-22 | — | — | EP | disclosed |
| WO-2005087739-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | THERAVANCE, INC. (US) | 2005-09-22 | — | — | WO | disclosed |