Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.36 |
| ▸ | DRD2 | P14416 | 3/20 | 0.36 |
| ▸ | HTR7 | P34969 | 3/20 | 0.36 |
| ▸ | HTR6 | P50406 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 6/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6017485 | 0.91 | CHRM3 (0.37) | HTR1ADRD2HTR7HTR6MEN1 | |
| SCHEMBL6017445 | 0.83 | CHRM2 (0.39) | MEN1KMT2AALDH1A1MAPK1POLB | |
| SCHEMBL6016864 | 0.81 | BCHE (0.37) | HTR1ADRD2HTR7HTR6ALDH1A1 | |
| SCHEMBL6017518 | 0.77 | HTR1A (0.37) | HTR1ADRD2HTR7HTR6MEN1 | |
| SCHEMBL2639275 | 0.76 | CHRM2 (0.45) | MEN1KMT2AALDH1A1CHRM3RAB9A | |
| SCHEMBL6028157 | 0.76 | ACHE (0.39) | HTR1ADRD2HTR7HTR6ALDH1A1 | |
| SCHEMBL1362067 | 0.75 | CHRM3 (0.62) | CHRM3SLC2A1 | |
| SCHEMBL4691377 | 0.73 | KMT2A (0.36) | HTR1ADRD2HTR7HTR6KMT2A | |
| SCHEMBL6021912 | 0.72 | CHRM2 (0.56) | ALDH1A1RAB9A | |
| SCHEMBL4695275 | 0.71 | CHRM2 (0.35) | MEN1KMT2AALDH1A1CHRM3GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1723112-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | Theravance, Inc. (US) | 2006-11-22 | — | — | EP | disclosed |
| WO-2005087736-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | THERAVANCE, INC. (US) | 2005-09-22 | — | — | WO | disclosed |