Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 3/20 | 0.36 |
| ▸ | CTSK | P43235 | 10/20 | 0.35 |
| ▸ | CTSS | P25774 | 7/20 | 0.35 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.34 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 4/20 | 0.34 |
| ▸ | CTSB | P07858 | 2/20 | 0.33 |
| ▸ | CTSD | P07339 | 1/20 | 0.33 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.33 |
| ▸ | PPIA | P62937 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4419835 | 0.82 | JAK2 (0.37) | — | |
| SCHEMBL23299665 | 0.82 | CTSL (0.38) | CTSLCTSKCTSSDRD2CTSB | |
| SCHEMBL7608833 | 0.81 | CTSL (0.43) | CTSLCTSKCTSSCTSBCTSD | |
| SCHEMBL27648998 | 0.80 | JAK2 (0.37) | CTSLCTSKCTSSCTSBCTSD | |
| SCHEMBL4418580 | 0.79 | JAK2 (0.39) | — | |
| SCHEMBL3370066 | 0.78 | CTSL (0.41) | CTSLCTSKCTSSCTSB | |
| SCHEMBL22765979 | 0.77 | P2RX7 (0.41) | CTSLCTSKCTSSCTSB | |
| SCHEMBL23276791 | 0.75 | CTSL (0.39) | CTSLCTSKCTSSCTSBCTSD | |
| SCHEMBL20328214 | 0.73 | DRD2 (0.39) | CTSLCTSKNPFFR1NPFFR2DRD2 | |
| SCHEMBL20069700 | 0.72 | CACNA1H (0.37) | CTSLCTSKNPFFR1NPFFR2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1699795-A1 | SUBSTITUTED 8'-PYRI(MI)DINYL-DIHYDROSPIRO-[CYCLOALKLYMINE]-PYRIMIDO[1,2A]PYRIMIDIN-6-ONE DERIVATIVES | Sanofi-Aventis (FR) | 2006-09-13 | — | — | EP | disclosed |
| WO-2005058908-A1 | SUBSTITUTED 8’-PYRI(MI)DINYL-DIHYDROSPIRO-[CYCLOALKYLAMINE]-PYRIMIDO[1,2-a]PYRIMIDIN-6-ONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2005-06-30 | — | — | WO | disclosed |