SCHEMBL6017582

SCHEMBL6017582

COc1ccccc1N1CCN(CCCCN2C(=O)CCC2=O)CC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR7 P34969 4/20 1.00
HTR1A P08908 4/20 1.00
MEN1 O00255 2/20 1.00
KMT2A Q03164 2/20 1.00
CYP1A2 P05177 1/20 1.00
CYP2C9 P11712 1/20 1.00
CYP2C19 P33261 1/20 1.00
ADRA1D P25100 6/20 0.76
ADRA1A P35348 6/20 0.76
ADRA1B P35368 6/20 0.76
ALDH1A1 P00352 2/20 0.76
CYP3A4 P08684 1/20 0.76
CYP2D6 P10635 1/20 0.76
ALOX12 P18054 1/20 0.76
HIF1A Q16665 1/20 0.76
HSD17B10 Q99714 1/20 0.76
DRD2 P14416 3/20 0.74
DRD3 P35462 3/20 0.74
DRD5 P21918 1/20 0.74
KDM4E B2RXH2 1/20 0.74

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5592295 0.99 HTR7 (0.97) HTR7HTR1AMEN1KMT2ACYP1A2
Hydrochloric Acid SCHEMBL6864309 0.99 HTR7 (0.97) HTR7HTR1AMEN1KMT2ACYP1A2
Hydrochloric Acid SCHEMBL5592269 0.97 HTR7 (0.95) HTR7HTR1AMEN1KMT2ACYP1A2
SCHEMBL6866109 0.97 HTR7 (0.95) HTR7HTR1AMEN1KMT2ACYP1A2
Hydrochloric Acid SCHEMBL7658210 0.96 HTR7 (0.93) HTR7HTR1AMEN1KMT2ACYP1A2
SCHEMBL7671770 0.95 HTR7 (0.91) HTR7HTR1AMEN1KMT2ACYP1A2
Hydrochloric Acid SCHEMBL6867322 0.94 HTR7 (0.88) HTR7HTR1AMEN1KMT2ACYP1A2
SCHEMBL5592202 0.94 HTR7 (0.88) HTR7HTR1AMEN1KMT2ACYP1A2
Hydrochloric Acid SCHEMBL5592194 0.93 HTR7 (0.86) HTR7HTR1AMEN1KMT2ACYP1A2
SCHEMBL4877989 0.93 HTR7 (0.86) HTR7HTR1AMEN1KMT2ACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-222482501-U Large-field double telecentric lens 华侨大学 2025-02-14 CN claimed
US-20050080084-A1 Compositions of a cyclooxygenase-2 selective inhibitor and a serotonin-modulating agent for the treatment of central nervous system damage PHARMACIA CORPORATION 2005-04-14 US claimed
WO-2005018541-A2 COX-2 INHIBITOR AND SEROTONIN MODULATOR FOR TREATING CNS DAMAGE PHARMACIA CORPORATION (US) 2005-03-03 WO claimed
US-6420366-B1 PERIPHERAL VASCULAR DISEASE, CONGESTIVE HEART FAILURE, HYPERTENSION AND ESPECIALLY BENIGN PROSTATIC HYPERTROPHY. RANBAXY LABORATORIES LIMITED (IN) 2002-07-16 US claimed
US-6083950-A TREATMENT OF PERIPHERAL VASCULAR DISEASE, CONGESTIVE HEART FAILURE, HYPERTENSION AND ESPECIALLY BENIGN PROSTATIC HYPERTROPHY RANBAXY LABORATORIES LIMITED (IN) 2000-07-04 US claimed
WO-2000005206-A1 ARYLPIPERAZINE DERIVATIVES USEFUL AS URO-SELECTIVE ALPHA-1-ADRENOCEPTOR BLOCKERS RANBAXY LABORATORIES LIMITED (US) 2000-02-03 WO claimed
CN-222482501-U Large-field double telecentric lens 华侨大学 2025-02-14 CN disclosed
US-9034798-B2 Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions CAPROTEC BIOANALYTICS GMBH (DE) 2015-05-19 US disclosed
US-8569481-B2 Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions PHARMACEUTICALS, INC. (US) 2013-10-29 US disclosed
US-7858560-B2 Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions CAPROTEC BIOANALYTICS GMBH (DE) 2010-12-28 US disclosed
US-20100298168-A1 Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions HK PHARMACEUTICALS, INC. 2010-11-25 US disclosed
US-20100248264-A1 Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions HK PHARMACEUTICALS, INC. 2010-09-30 US disclosed
EP-1660079-A2 COMPOSITIONS OF A CYCLOOXYGENASE-2 SELECTIVE INHIBITOR AND A SEROTONIN MODULATING AGENT FOR THE TREATMENT OF NEOPLASIA Pharmacia Corporation (US) 2006-05-31 EP disclosed
US-6420559-B1 THE COMPOUNDS ARE USEFUL FOR TREATMENT OF DISEASE CONDITIONS, SUCH AS PERIPHERAL VASCULAR DISEASE, CONGESTIVE HEART FAILURE, HYPERTENSION AND ESPECIALLY BENIGN PROSTATIC HYPERTROPHY. RANBAXY LABORATORIES LIMITED (IN) 2002-07-16 US disclosed
US-6420366-B1 PERIPHERAL VASCULAR DISEASE, CONGESTIVE HEART FAILURE, HYPERTENSION AND ESPECIALLY BENIGN PROSTATIC HYPERTROPHY. RANBAXY LABORATORIES LIMITED (IN) 2002-07-16 US disclosed
US-6410735-B1 CONGESTIVE HEART FAILURE; HYPOTENSIVE AGENTS; BENGIN PROSTATIC HYPERPLASIA RANBAXY LABORATORIES LIMITED (IN) 2002-06-25 US disclosed
EP-1097134-A1 ARYLPIPERAZINE DERIVATIVES USEFUL AS UROSELECTIVE ALPHA1-ADRENOCEPTOR BLOCKERS RANBAXY LABORATORIES, LTD. (IN) 2001-05-09 EP disclosed
US-6090809-A 1-(4-arylpiperazin-1-yl)-ω-[n-(α..omega.-dicarboximido)]-alkanes useful as uro-selective α1 -adrenoceptor blockers RANBAXY LABORATORIES LIMITED (IN) 2000-07-18 US disclosed
US-6083950-A TREATMENT OF PERIPHERAL VASCULAR DISEASE, CONGESTIVE HEART FAILURE, HYPERTENSION AND ESPECIALLY BENIGN PROSTATIC HYPERTROPHY RANBAXY LABORATORIES LIMITED (IN) 2000-07-04 US disclosed
WO-2000005205-A1 ARYLPIPERAZINE DERIVATIVES USEFUL AS UROSELECTIVE ALPHA1-ADRENOCEPTOR BLOCKERS RANBAXY LABORATORIES LIMITED (US) 2000-02-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050080084-A1 Compositions of a cyclooxygenase-2 selective inhibitor and a serotonin-modulating agent for the treatment of central nervous system damage TPH2, TPH1, HTR2A HTR7 25/4885HTR1A 6/4885MEN1 3935/4885
US-20100298168-A1 Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions CHLSN, PTMS, SRMS HTR7 4427/4885HTR1A 4686/4885MEN1 2224/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.