Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Binifibrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA known ✓ | Q07869 | 5/20 | 0.53 |
| ▸ | PPARG known ✓ | P37231 | 1/20 | 0.53 |
| ▸ | PPARD known ✓ | Q03181 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | FABP2 | P12104 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Binifibrate SCHEMBL3654211 | 1.00 | PPARA (0.53) | PPARASMN1; SMN2ALDH1A1FABP2PPARG | |
| Binifibrate SCHEMBL3959320 | 0.91 | LMNA (0.52) | PPARASMN1; SMN2ALDH1A1FABP2PPARG | |
| Bezafibrate SCHEMBL7079797 | 0.82 | PPARA (0.77) | PPARASMN1; SMN2ALDH1A1FABP2PPARG | |
| Binifibrate SCHEMBL49116 | 0.78 | KMT2A (0.51) | PPARASMN1; SMN2ALDH1A1PPARGMAPT | |
| Binifibrate SCHEMBL29388376 | 0.78 | KMT2A (0.51) | PPARASMN1; SMN2ALDH1A1PPARGMAPT | |
| Bezafibrate SCHEMBL5077755 | 0.72 | PPARA (1.00) | PPARASMN1; SMN2ALDH1A1FABP2PPARG | |
| Bezafibrate SCHEMBL16299 | 0.72 | PPARA (1.00) | PPARASMN1; SMN2ALDH1A1FABP2PPARG | |
| SCHEMBL11759022 | 0.72 | KMT2A (0.67) | PPARASMN1; SMN2ALDH1A1FABP2PPARG | |
| Bezafibrate SCHEMBL22364278 | 0.72 | PPARA (0.98) | PPARASMN1; SMN2ALDH1A1FABP2PPARG | |
| Bezafibrate SCHEMBL3088387 | 0.72 | PPARA (0.98) | PPARASMN1; SMN2ALDH1A1FABP2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1684704-A2 | COMPOSITIONS AND METHODS FOR INCREASING HDL AND HDL-2B LEVELS | Tawakol, Raif M. (US) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005041878-A2 | COMPOSITIONS AND METHODS FOR INCREASING HDL AND HDL-2B LEVELS | TAWAKOL RAIF M D (US) | 2005-05-12 | — | — | WO | disclosed |