Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Binifibrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA known ✓ | Q07869 | 6/20 | 0.52 |
| ▸ | LMNA | P02545 | 6/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | BLM | P54132 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 3/20 | 0.38 |
| ▸ | FABP2 | P12104 | 2/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Binifibrate SCHEMBL6017635 | 0.91 | PPARA (0.53) | LMNAPPARACYP2C9TSHRBLM | |
| Binifibrate SCHEMBL3654211 | 0.91 | PPARA (0.53) | LMNAPPARACYP2C9TSHRBLM | |
| Binifibrate SCHEMBL49116 | 0.87 | KMT2A (0.51) | LMNAPPARACYP2C9TSHRBLM | |
| Binifibrate SCHEMBL29388376 | 0.87 | KMT2A (0.51) | LMNAPPARACYP2C9TSHRBLM | |
| SCHEMBL22607962 | 0.78 | ALDH1A1 (0.49) | LMNAPPARACYP2C9TSHRBLM | |
| SCHEMBL28434613 | 0.77 | KMT2A (0.41) | LMNAPPARACYP2C9TSHRBLM | |
| Fenofibrate SCHEMBL6901888 | 0.75 | PPARA (0.69) | LMNAPPARACYP2C9TSHRBLM | |
| Etofibrate SCHEMBL3122 | 0.73 | L3MBTL1 (0.55) | LMNAPPARACYP2C9TSHRKMT2A | |
| Etofibrate SCHEMBL8168409 | 0.73 | L3MBTL1 (0.55) | LMNAPPARACYP2C9TSHRKMT2A | |
| Etofibrate SCHEMBL29801484 | 0.73 | L3MBTL1 (0.55) | LMNAPPARACYP2C9TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009033078-A2 | COMPOSITIONS AND METHODS FOR CONTROLLING CHOLESTEROL LEVELS | TAWAKOL RAIF (US) | 2009-03-12 | — | — | WO | disclosed |