Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 2/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.44 |
| ▸ | INSR | P06213 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5566249 | 0.94 | MAPK10 (0.45) | MAPK10MAPK8MAPK9INSRIGF1R | |
| SCHEMBL7707034 | 0.66 | MAPK10 (0.45) | MAPK10MAPK8MAPK9NPC1RAB9A | |
| SCHEMBL2878601 | 0.64 | MAPK10 (0.52) | MAPK10MAPK8MAPK9MKNK1MKNK2 | |
| SCHEMBL7707445 | 0.62 | MAPK10 (0.33) | MAPK10MAPK8MAPK9 | |
| SCHEMBL21067982 | 0.62 | MAPK10 (1.00) | MAPK10MAPK8MAPK9MKNK1MKNK2 | |
| SCHEMBL29432586 | 0.62 | MAPK10 (1.00) | MAPK10MAPK8MAPK9MKNK1MKNK2 | |
| SCHEMBL186278 | 0.62 | MAPK10 (1.00) | MAPK10MAPK8MAPK9MKNK1MKNK2 | |
| SCHEMBL6017572 | 0.61 | MAPK9 (0.40) | MAPK10MAPK8MAPK9MKNK1MKNK2 | |
| SCHEMBL17709604 | 0.60 | MAPK10 (0.56) | MAPK10MAPK8MAPK9KDRMKNK1 | |
| SCHEMBL5617848 | 0.59 | MAPK8 (0.49) | MAPK10MAPK8MAPK9INSRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1696909-A1 | BENZOTHIAZOLE DERIVATIVES FOR THE TREATMENT OF DIABETES | Applied Research Systems ARS Holding N.V. (AN) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005025567-A1 | BENZOTHIAZOLE DERIVATIVES FOR THE TREATMENT OF DIABETES | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2005-03-24 | — | — | WO | disclosed |