Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 2/20 | 0.38 |
| ▸ | C1S | P09871 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 7/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6019752 | 0.84 | MAPK14 (0.49) | PLK1MAPTSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL5718225 | 0.81 | MAPT (0.38) | PLK1PLAUC1SMAPTSMN1; SMN2 | |
| SCHEMBL1797326 | 0.79 | KDM4E (0.55) | PLK1PLAUC1SMAPTSMN1; SMN2 | |
| SCHEMBL1801707 | 0.78 | PLK1 (0.43) | PLK1PLAUC1SMAPTSMN1; SMN2 | |
| SCHEMBL6454412 | 0.76 | MAPK1 (0.52) | PLK1PLAUC1S | |
| SCHEMBL6883034 | 0.74 | PLK1 (0.65) | PLK1MAPTSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL6456041 | 0.74 | SMN1; SMN2 (0.63) | PLK1PLAUC1SMAPTSMN1; SMN2 | |
| SCHEMBL6018784 | 0.72 | ALDH1A1 (0.52) | MAPTSMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL6018650 | 0.71 | ALDH1A1 (0.38) | PLAUMAPTSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL6255667 | 0.70 | ALDH1A1 (0.52) | MAPTSMN1; SMN2ALDH1A1TP53KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1412347-B1 | PROCESS FOR THE PREPARATION OF HETEROCYCLIC PENTALENE DERIVATIVES | BASELL POLYOLEFINE GMBH (DE) | 2006-01-11 | — | — | EP | disclosed |
| US-6930190-B2 | Process for the preparation of heterocyclic pentalene derivatives | BASELL POLYOLEFINE GMBH (DE) | 2005-08-16 | — | — | US | disclosed |
| US-20040192931-A1 | Process for the preparation of heterocyclic pentalene derivatives | EQUISTAR CHEMICALS, LP | 2004-09-30 | — | — | US | disclosed |
| EP-1412347-A1 | PROCESS FOR THE PREPARATION OF HETEROCYCLIC PENTALENE DERIVATIVES | Basell Polyolefine GmbH (DE) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003014107-A1 | PROCESS FOR THE PREPARATION OF HETEROCYCLIC PENTALENE DERIVATIVES | BASELL POLYOLEFINE GMBH (DE) | 2003-02-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040192931-A1 | Process for the preparation of heterocyclic pentalene derivatives | CBR3, CBR1, ADH5 | PLK1 4227/4885PLAU 4159/4885C1S 1615/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.