Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.52 |
| ▸ | HPGD | P15428 | 7/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | GRM6 | O15303 | 3/20 | 0.48 |
| ▸ | CDC7 | O00311 | 1/20 | 0.48 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.48 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6018669 | 0.87 | MAPK14 (0.65) | ALDH1A1HPGDKDM4ETDP1L3MBTL1 | |
| SCHEMBL14234474 | 0.85 | ALDH1A1 (0.59) | ALDH1A1HPGDKDM4ETDP1L3MBTL1 | |
| SCHEMBL1029314 | 0.82 | PLK1 (0.62) | ALDH1A1HPGDKDM4ETDP1L3MBTL1 | |
| SCHEMBL1797326 | 0.80 | KDM4E (0.55) | ALDH1A1HPGDKDM4EMAPTRAB9A | |
| SCHEMBL1801707 | 0.79 | PLK1 (0.43) | ALDH1A1HPGDKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL13088494 | 0.79 | HPGD (0.60) | ALDH1A1HPGDKDM4ETDP1L3MBTL1 | |
| SCHEMBL6454412 | 0.78 | MAPK1 (0.52) | MAPK1 | |
| SCHEMBL9825151 | 0.77 | ALDH1A1 (0.51) | ALDH1A1HPGDKDM4ETDP1L3MBTL1 | |
| SCHEMBL5033848 | 0.76 | IL2 (0.46) | ALDH1A1KDM4EMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL4830396 | 0.76 | TSHR (0.63) | ALDH1A1HPGDKDM4ETDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040072871-A1 | Novel thiophene derivatives, their process of preparation and the pharmaceutical compositions which comprise them | WARNER-LAMBERT COMPANY LLC | 2004-04-15 | — | — | US | claimed |
| EP-1854804-B1 | Heterocyclic metallocene compounds and use thereof in catalyst systems for producing olefin polymers | BASELL POLYOLEFINE GMBH (DE) | 2011-05-04 | — | — | EP | disclosed |
| EP-1412347-B1 | PROCESS FOR THE PREPARATION OF HETEROCYCLIC PENTALENE DERIVATIVES | BASELL POLYOLEFINE GMBH (DE) | 2006-01-11 | — | — | EP | disclosed |
| US-6930190-B2 | Process for the preparation of heterocyclic pentalene derivatives | BASELL POLYOLEFINE GMBH (DE) | 2005-08-16 | — | — | US | disclosed |
| US-20040192931-A1 | Process for the preparation of heterocyclic pentalene derivatives | EQUISTAR CHEMICALS, LP | 2004-09-30 | — | — | US | disclosed |
| EP-1412347-A1 | PROCESS FOR THE PREPARATION OF HETEROCYCLIC PENTALENE DERIVATIVES | Basell Polyolefine GmbH (DE) | 2004-04-28 | — | — | EP | disclosed |
| US-20040072871-A1 | Novel thiophene derivatives, their process of preparation and the pharmaceutical compositions which comprise them | WARNER-LAMBERT COMPANY LLC | 2004-04-15 | — | — | US | disclosed |
| WO-2003014107-A1 | PROCESS FOR THE PREPARATION OF HETEROCYCLIC PENTALENE DERIVATIVES | BASELL POLYOLEFINE GMBH (DE) | 2003-02-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040192931-A1 | Process for the preparation of heterocyclic pentalene derivatives | CBR3, CBR1, ADH5 | ALDH1A1 805/4885HPGD 330/4885KDM4E 3121/4885 |
| US-20040072871-A1 | Novel thiophene derivatives, their process of preparation and the pharmaceutical compositions which comprise them | MMP11, MMP13, CBR1 | ALDH1A1 563/4885HPGD 612/4885KDM4E 2797/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.