Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.38 |
| ▸ | GRM6 | O15303 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6018804 | 0.84 | PLK1 (0.38) | MAPK14HPGDMAPTNPC1SMN1; SMN2 | |
| SCHEMBL6018664 | 0.83 | MAPK14 (0.45) | MAPK14OPRD1HPGDMAPTNPC1 | |
| SCHEMBL1825175 | 0.79 | MAPK14 (0.60) | MAPK14OPRD1HPGDMAPTNPC1 | |
| SCHEMBL12496517 | 0.76 | MAPK14 (0.61) | MAPK14OPRD1HPGDMAPTNPC1 | |
| SCHEMBL6692978 | 0.72 | MAPT (0.51) | MAPK14OPRD1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL12396903 | 0.72 | OPRD1 (0.73) | MAPK14OPRD1HPGDMAPTNPC1 | |
| SCHEMBL6018669 | 0.69 | MAPK14 (0.65) | MAPK14OPRD1HPGDMAPTNPC1 | |
| SCHEMBL761381 | 0.68 | CES2 (0.65) | HPGDMAPTSMN1; SMN2HSD17B10HTT | |
| SCHEMBL29147820 | 0.68 | CES2 (0.56) | MAPTNPC1SMN1; SMN2RAB9AGSK3B | |
| SCHEMBL10476789 | 0.66 | CES2 (0.67) | MAPTSMN1; SMN2HTTALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1412347-B1 | PROCESS FOR THE PREPARATION OF HETEROCYCLIC PENTALENE DERIVATIVES | BASELL POLYOLEFINE GMBH (DE) | 2006-01-11 | — | — | EP | disclosed |
| US-6930190-B2 | Process for the preparation of heterocyclic pentalene derivatives | BASELL POLYOLEFINE GMBH (DE) | 2005-08-16 | — | — | US | disclosed |
| US-20040192931-A1 | Process for the preparation of heterocyclic pentalene derivatives | EQUISTAR CHEMICALS, LP | 2004-09-30 | — | — | US | disclosed |
| EP-1412347-A1 | PROCESS FOR THE PREPARATION OF HETEROCYCLIC PENTALENE DERIVATIVES | Basell Polyolefine GmbH (DE) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003014107-A1 | PROCESS FOR THE PREPARATION OF HETEROCYCLIC PENTALENE DERIVATIVES | BASELL POLYOLEFINE GMBH (DE) | 2003-02-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040192931-A1 | Process for the preparation of heterocyclic pentalene derivatives | CBR3, CBR1, ADH5 | MAPK14 825/4885OPRD1 299/4885HPGD 330/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.