SCHEMBL6019248

SCHEMBL6019248

Cn1cc(C(=O)Nc2ccccc2-c2ccccn2)c(C(F)(F)F)n1

nearest known ligand 0.53

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.53
POLB P06746 1/20 0.53
S1PR1 P21453 3/20 0.49
S1PR3 Q99500 3/20 0.49
ATM Q13315 1/20 0.44
NTRK1 P04629 3/20 0.43
PDE10A Q9Y233 1/20 0.42
ATR Q13535 1/20 0.42
SCN9A Q15858 2/20 0.41
STING1 Q86WV6 1/20 0.41
SCN5A Q14524 1/20 0.41
DGAT1 O75907 1/20 0.41
GAA P10253 1/20 0.41
GLA P06280 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6019292 0.85 LMNA (0.51) LMNAPOLBATMNTRK1STING1
SCHEMBL1085471 0.84 LMNA (0.57) LMNAPOLBS1PR1S1PR3ATM
SCHEMBL6019010 0.84 ATM (0.47) S1PR1S1PR3ATMATR
SCHEMBL13936356 0.83 LMNA (0.56) LMNAPOLBATMNTRK1STING1
SCHEMBL29369397 0.83 LMNA (0.56) LMNAPOLBATMNTRK1STING1
SCHEMBL303186 0.83 LMNA (0.56) LMNAPOLBATMNTRK1STING1
SCHEMBL122740 0.83 LMNA (0.56) LMNAPOLBATMNTRK1STING1
SCHEMBL27737488 0.82 POLB (0.55) LMNAPOLBATMNTRK1STING1
SCHEMBL302989 0.82 POLB (0.61) LMNAPOLBATMNTRK1STING1
SCHEMBL4100577 0.81 LMNA (0.54) LMNAPOLBATMNTRK1STING1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060178513-A1 Pyridinylanilides BAYER CROPSCIENCE AG (DE) 2006-08-10 US disclosed
EP-1656020-A2 PYRIDINYLANILIDES Bayer CropScience AG (DE) 2006-05-17 EP disclosed
WO-2005004606-A2 PYRIDINYLANILIDES BAYER CROPSCIENCE AG (DE) 2005-01-20 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060178513-A1 Pyridinylanilides C3AR1, C5, PADI1 LMNA 3099/4885POLB 930/4885S1PR1 1578/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.