SCHEMBL303186

SCHEMBL303186

Cn1cc(C(=O)Nc2ccccc2-c2ccccc2F)c(C(F)(F)F)n1

nearest known ligand 0.56

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.56
POLB P06746 1/20 0.56
ATM Q13315 1/20 0.46
NTRK1 P04629 2/20 0.45
CHRM3 P20309 3/20 0.43
STING1 Q86WV6 1/20 0.43
GAA P10253 1/20 0.43
BACE1 P56817 2/20 0.42
BACE2 Q9Y5Z0 2/20 0.42
HTT P42858 1/20 0.42
WDR5 P61964 1/20 0.42
DHODH Q02127 1/20 0.42
IRAK4 Q9NWZ3 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL120547 0.90 LMNA (0.54) LMNAPOLBATMNTRK1STING1
SCHEMBL15063349 0.90 LMNA (0.51) LMNAPOLBNTRK1CHRM3STING1
SCHEMBL29419095 0.90 LMNA (0.54) LMNAPOLBATMNTRK1STING1
SCHEMBL675130 0.90 LMNA (0.51) LMNAPOLBATMNTRK1CHRM3
SCHEMBL1085546 0.90 LMNA (0.53) LMNAPOLBATMNTRK1CHRM3
SCHEMBL29390999 0.90 LMNA (0.53) LMNAPOLBATMNTRK1CHRM3
SCHEMBL4107917 0.89 LMNA (0.64) LMNAPOLBNTRK1CHRM3BACE1
SCHEMBL1085759 0.89 LMNA (0.55) LMNAPOLBATMNTRK1STING1
SCHEMBL4447678 0.88 LMNA (0.60) LMNAPOLBNTRK1CHRM3BACE1
SCHEMBL122740 0.88 LMNA (0.56) LMNAPOLBATMNTRK1STING1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 91 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2489262-B1 PESTICIDAL MIXTURES COMPRISING AN ANTHRANILAMIDE INSECTICIDE AND A FUNGICIDE BASF SE (DE) 2018-11-14 EP claimed
US-20150080215-A1 TERNARY PESTICIDAL MIXTURES BASF SE (DE) 2015-03-19 US claimed
US-20140179518-A1 Pesticidal Mixtures Comprising Cyanosulfoximine Compounds BASF SE (DE) 2014-06-26 US claimed
US-20130267414-A1 PESTICIDAL MIXTURES BASF SE (DE) 2013-10-10 US claimed
US-20130137571-A1 Crystalline Modification of Fipronil BASF SE (DE) 2013-05-30 US claimed
EP-2489263-A2 Pesticidal mixtures comprising an anthranilamide insecticide and a fungicide BASF SE (DE) 2012-08-22 EP claimed
EP-2489262-A2 Pesticidal mixtures comprising an anthranilamide insecticide and a fungicide BASF SE (DE) 2012-08-22 EP claimed
EP-2489264-A2 Pesticidal mixtures comprising an anthranilamide insecticide and a carboxamide fungicide BASF SE (DE) 2012-08-22 EP claimed
JP-2012500824-A 2012-01-12 JP claimed
US-20110160054-A1 Pesticidal Mixtures Comprising Cyanosulfoximine Compounds and Spinetoram BASF SE (DE) 2011-06-30 US claimed
US-20100029698-A1 Pesticidal Mixtures BASF SE (DE) 2010-02-04 US claimed
US-20100022389-A1 Pesticidal Mixtures BASF SE (DE) 2010-01-28 US claimed
EP-2109366-A2 PESTICIDAL MIXTURES BASF SE (DE) 2009-10-21 EP claimed
EP-2091331-A2 PESTICIDAL MIXTURES COMPRISING AN ANTHRANILAMIDE INSECTICIDE AND A FUNGICIDE BASF SE (DE) 2009-08-26 EP claimed
EP-2091330-A2 PESTICIDAL MIXTURES COMPRISING AN ANTHRANILAMIDE INSECTICIDE AND A FUNGICIDE BASF SE (DE) 2009-08-26 EP claimed
WO-2009065834-A2 FUNGICIDAL MIXTURES BASF SE (DE) 2009-05-28 WO claimed
WO-2009007233-A2 PESTICIDAL MIXTURES COMPRISING SULFONAMIDES AND ONE OR MORE FUNGICIDES BASF SE (DE) 2009-01-15 WO claimed
WO-2008095913-A2 PESTICIDAL MIXTURES BASF SE (DE) 2008-08-14 WO claimed
WO-2008034787-A2 PESTICIDAL MIXTURES COMPRISING AN ANTHRANILAMIDE INSECTICIDE AND A FUNGICIDE BASF SE (DE) 2008-03-27 WO claimed
WO-2008034785-A2 PESTICIDAL MIXTURES COMPRISING AN ANTHRANILAMIDE INSECTICIDE AND A FUNGICIDE BASF SE (DE) 2008-03-27 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100022389-A1 Pesticidal Mixtures AADAC, CTRL, AAAS LMNA 3546/4885POLB 4261/4885ATM 3845/4885
US-20100029698-A1 Pesticidal Mixtures PTMS, THOP1, MLN LMNA 3839/4885POLB 4074/4885ATM 4824/4885
US-20130267414-A1 PESTICIDAL MIXTURES AADAC, CTRL, AAAS LMNA 3546/4885POLB 4261/4885ATM 3845/4885
US-20140179518-A1 Pesticidal Mixtures Comprising Cyanosulfoximine Compounds CPN1, SRM, STS LMNA 3355/4885POLB 3649/4885ATM 3643/4885
US-20130137571-A1 Crystalline Modification of Fipronil FIP1L1, PTMS, FIBP LMNA 2209/4885POLB 4375/4885ATM 4853/4885
US-20110160054-A1 Pesticidal Mixtures Comprising Cyanosulfoximine Compounds and Spinetoram CHRM3, CHRM2, BRS3 LMNA 2976/4885POLB 4836/4885ATM 1872/4885
US-20150080215-A1 TERNARY PESTICIDAL MIXTURES AADAC, AS3MT, DDT LMNA 4360/4885POLB 4562/4885ATM 2484/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.