Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11880401 | 0.81 | ALDH1A1 (0.41) | ALDH1A1KDM4EHPGDLMNATSHR | |
| SCHEMBL2958001 | 0.78 | ALDH1A1 (0.56) | ALDH1A1KDM4EHPGDLMNATSHR | |
| SCHEMBL10457804 | 0.77 | ALDH1A1 (0.54) | ALDH1A1KDM4EHPGDLMNATSHR | |
| SCHEMBL1663643 | 0.77 | NOS2 (0.55) | ALDH1A1KDM4EHPGDLMNATSHR | |
| SCHEMBL5851401 | 0.77 | SMN1; SMN2 (0.55) | ALDH1A1KDM4EHPGDLMNATSHR | |
| SCHEMBL5851398 | 0.77 | ALDH1A1 (0.54) | ALDH1A1KDM4EHPGDLMNATSHR | |
| SCHEMBL30034162 | 0.77 | SMN1; SMN2 (0.55) | ALDH1A1KDM4EHPGDLMNATSHR | |
| SCHEMBL3968510 | 0.77 | CYP2C9 (0.62) | ALDH1A1KDM4EHPGDLMNATSHR | |
| SCHEMBL12937256 | 0.76 | MAPK1 (0.74) | ALDH1A1KDM4EHPGDLMNATSHR | |
| SCHEMBL17378596 | 0.74 | MAPK1 (0.59) | ALDH1A1KDM4EHPGDLMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613626-A1 | CYCLIC BENZIMIDAZOLES | ALTANA Pharma AG (DE) | 2006-01-11 | — | — | EP | disclosed |
| WO-2004087701-A1 | CYCLIC BENZIMIDAZOLES | ALTANA PHARMA AG (DE) | 2004-10-14 | — | — | WO | disclosed |
| US-4031107-A | Method for introducing amino groups into benzimidazole or imidazopyridine compounds | ELI LILLY AND COMPANY (US) | 1977-06-21 | — | — | US | disclosed |