Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.50 |
| ▸ | PPARD | Q03181 | 2/20 | 0.50 |
| ▸ | PPARA | Q07869 | 2/20 | 0.50 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.46 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.45 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2434205 | 0.81 | NR4A2 (0.58) | SRD5A2LTB4RLTB4R2HPGDTSHR | |
| SCHEMBL2433126 | 0.80 | LTB4R (0.55) | PPARGPPARDPPARASRD5A2LTB4R | |
| SCHEMBL2085650 | 0.80 | CNR1 (0.47) | PPARGPPARDPPARASRD5A2LTB4R | |
| SCHEMBL7448891 | 0.79 | SRD5A2 (0.48) | PPARGPPARDPPARASRD5A2NPC1 | |
| SCHEMBL2085331 | 0.79 | KDM4E (0.51) | MAPTHPGDTSHRKDM4ELMNA | |
| SCHEMBL27732143 | 0.78 | CNR1 (0.49) | PPARGPPARDPPARASRD5A2LTB4R | |
| SCHEMBL9525686 | 0.78 | LTB4R (0.59) | PPARGPPARDPPARALTB4RLTB4R2 | |
| SCHEMBL4012453 | 0.77 | KDM4E (0.65) | MAPTHPGDTSHRKDM4ELMNA | |
| SCHEMBL31498840 | 0.77 | KDM4E (0.65) | MAPTHPGDTSHRKDM4ELMNA | |
| SCHEMBL2081872 | 0.77 | ALDH1A1 (0.40) | MAPTHPGDTSHRKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1690538-A1 | ISOXAZOLE DERIVATIVE HAVING AGONISTIC ACTIVITY AGAINST PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR | SHIONOGI & CO., LTD. (JP) | 2006-08-16 | — | — | EP | disclosed |