Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 5/20 | 0.59 |
| ▸ | LTB4R2 | Q9NPC1 | 4/20 | 0.59 |
| ▸ | PLA2G2A | P14555 | 7/20 | 0.59 |
| ▸ | PPARG | P37231 | 2/20 | 0.56 |
| ▸ | PPARD | Q03181 | 2/20 | 0.56 |
| ▸ | PPARA | Q07869 | 2/20 | 0.56 |
| ▸ | F2 | P00734 | 1/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.51 |
| ▸ | ICMT | O60725 | 3/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8178172 | 0.79 | PLA2G2A (0.70) | PLA2G2APPARGPPARDPPARAICMT | |
| SCHEMBL8298657 | 0.78 | PPARD (0.65) | LTB4RLTB4R2PLA2G2APPARGPPARD | |
| SCHEMBL8299582 | 0.78 | PLA2G2A (0.78) | LTB4RLTB4R2PLA2G2APPARGPPARD | |
| SCHEMBL6021902 | 0.78 | PPARG (0.50) | LTB4RLTB4R2PPARGPPARDPPARA | |
| SCHEMBL27386831 | 0.77 | LTB4R (0.64) | LTB4RLTB4R2PLA2G2APPARGPPARD | |
| SCHEMBL27384853 | 0.76 | PLA2G2A (0.63) | LTB4RLTB4R2PLA2G2APPARGPPARD | |
| SCHEMBL9023728 | 0.76 | LTB4R (0.85) | LTB4RLTB4R2 | |
| SCHEMBL23886848 | 0.75 | PLA2G4A (0.46) | LTB4RLTB4R2PLA2G2APPARGPPARD | |
| SCHEMBL30176331 | 0.75 | PLA2G4A (0.46) | LTB4RLTB4R2PLA2G2APPARGPPARD | |
| SCHEMBL13930968 | 0.75 | PPARD (0.68) | LTB4RLTB4R2PLA2G2APPARGPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0548250-A4 | SUBSTITUTED BICYCLIC ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B 4? ANTAGONIST ACTIVITY | — | 1993-10-27 | — | — | EP | disclosed |
| EP-0548250-A1 | SUBSTITUTED BICYCLIC ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B 4? ANTAGONIST ACTIVITY. | RHONE POULENC RORER INT (US) | 1993-06-30 | — | — | EP | disclosed |
| WO-1992004321-A1 | SUBSTITUTED BICYCLIC ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B4 ANTAGONIST ACTIVITY | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1992-03-19 | — | — | WO | disclosed |