Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR2 | O95136 | 2/20 | 0.48 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.48 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.48 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.41 |
| ▸ | CHRNA10 | Q9GZZ6 | 2/20 | 0.41 |
| ▸ | CHRNA9 | Q9UGM1 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ANPEP | P15144 | 2/20 | 0.40 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.40 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.40 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.39 |
| ▸ | CETP | P11597 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13851328 | 0.83 | ALDH1A1 (0.53) | KDM4EALDH1A1RAB9A | |
| Hydrochloric Acid SCHEMBL210855 | 0.82 | MEN1 (0.38) | KDM4EALDH1A1RAB9A | |
| SCHEMBL4230954 | 0.82 | CHRNA7 (0.55) | KDM4EALDH1A1RAB9ACHRNA7CHRNA10 | |
| Bromide SCHEMBL3361424 | 0.82 | ALDH1A1 (0.51) | KDM4EALDH1A1RAB9A | |
| SCHEMBL1226951 | 0.80 | MEN1 (0.39) | KDM4EALDH1A1RAB9A | |
| SCHEMBL19219091 | 0.80 | MEN1 (0.44) | S1PR2S1PR4S1PR1S1PR3KDM4E | |
| SCHEMBL17384186 | 0.79 | ALDH1A1 (0.49) | KDM4EALDH1A1RAB9A | |
| Hydrochloric Acid SCHEMBL603487 | 0.79 | ANPEP (0.36) | S1PR2S1PR4S1PR1S1PR3TSHR | |
| Bromide SCHEMBL918125 | 0.79 | MEN1 (0.38) | KDM4EALDH1A1RAB9A | |
| SCHEMBL25567518 | 0.77 | CHRNA7 (0.50) | KDM4EALDH1A1RAB9ACHRNA7CHRNA10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8786932-B2 | Advanced electrode structures and electrochromic devices | NTERA, INC. (US) | 2014-07-22 | — | — | US | claimed |
| US-20120038967-A1 | ADVANCED ELECTRODE STRUCTURES AND ELECTROCHROMIC DEVICES | NTERA LIMITED (IE) | 2012-02-16 | — | — | US | claimed |
| US-8786932-B2 | Advanced electrode structures and electrochromic devices | NTERA, INC. (US) | 2014-07-22 | — | — | US | disclosed |
| US-20120038967-A1 | ADVANCED ELECTRODE STRUCTURES AND ELECTROCHROMIC DEVICES | NTERA LIMITED (IE) | 2012-02-16 | — | — | US | disclosed |