Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GGPS1 | O95749 | 3/20 | 0.35 |
| ▸ | TYMS | P04818 | 1/20 | 0.35 |
| ▸ | ACP3 | P15309 | 1/20 | 0.31 |
| ▸ | CFTR | P13569 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1226951 | 0.98 | MEN1 (0.39) | MEN1KMT2ATP53CYP1A2CYP2D6 | |
| Bromide SCHEMBL918125 | 0.96 | MEN1 (0.38) | MEN1KMT2ATP53CYP1A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL3364505 | 0.91 | MEN1 (0.40) | MEN1KMT2ATP53CYP1A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL3780200 | 0.89 | PABPC1 (0.40) | MAPTLMNAGGPS1 | |
| Hydrochloric Acid SCHEMBL193627 | 0.89 | PABPC1 (0.40) | MAPTLMNAGGPS1 | |
| SCHEMBL9889761 | 0.88 | MEN1 (0.41) | MEN1KMT2ATP53CYP1A2CYP2D6 | |
| SCHEMBL13974630 | 0.88 | SLC6A4 (0.42) | MEN1KMT2ATP53CYP1A2CYP2D6 | |
| Bromide SCHEMBL5586402 | 0.88 | PABPC1 (0.39) | MEN1KMT2AMAPTLMNA | |
| Bromide SCHEMBL2462794 | 0.87 | SLC6A4 (0.41) | MEN1KMT2ATP53CYP1A2CYP2D6 | |
| SCHEMBL29201320 | 0.87 | MEN1 (0.40) | MEN1KMT2ATP53CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 122 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7253940-B2 | Nanoporous and nanocrystalline film and electrochromic device | UNIVERSITY COLLEGE DUBLIN, A CONSTITUENT COLLEGE OF THE NATIONAL UNIVERSITY OF IRELAND (IE) | 2007-08-07 | — | — | US | claimed |
| JP-3934420-B2 | — | — | 2007-06-20 | — | — | JP | claimed |
| CN-1315004-C | An improved electrochromic or electrodeposition display and process for their manufacture | SIPIX IMAGING INC (US) | 2007-05-09 | — | — | CN | claimed |
| US-20060139724-A1 | Electrochromic or electrodeposition display and novel process for their manufacture | E INK CORPORATION | 2006-06-29 | — | — | US | claimed |
| US-20060097233-A1 | Electrochromic particles | NTERA LIMITED (IE) | 2006-05-11 | — | — | US | claimed |
| US-20050128562-A1 | Nanoporous and nanocrystalline film and electrochromic device | UNIVERSITY COLLEGE DUBLIN, A CONSTITUENT COLLEGE OF THE NATIONAL UNIVERSITY OF IRELAND | 2005-06-16 | — | — | US | claimed |
| EP-0958526-B1 | ELECTROCHROMIC SYSTEM | UNIV DUBLIN (IE) | 2005-06-15 | — | — | EP | claimed |
| EP-1224505-B1 | ELECTROCHROMIC DEVICE | UNIV DUBLIN (IE) | 2005-01-12 | — | — | EP | claimed |
| EP-1443090-A1 | Electrochromic particles | Ntera Limited (IE) | 2004-08-04 | — | — | EP | claimed |
| CN-1482509-A | An improved electrochromic or electrodeposition display and process for their manufacture | ϣ | 2004-03-17 | — | — | CN | claimed |
| US-20030214695-A1 | ELECTRO-OPTIC DISPLAYS, AND METHODS FOR DRIVING SAME | E INK CORPORATION (US) | 2003-11-20 | — | — | US | claimed |
| JP-2003511837-A | — | — | 2003-03-25 | — | — | JP | claimed |
| EP-1224505-A1 | ELECTROCHROMIC DEVICE | UNIVERSITY COLLEGE DUBLIN (IE) | 2002-07-24 | — | — | EP | claimed |
| US-6301038-B1 | IN BUILDINGS AND AUTOMOBILES | UNIVERSITY COLLEGE DUBLIN (IE) | 2001-10-09 | — | — | US | claimed |
| WO-2001027690-A2 | ELECTROCHROMIC DEVICE | UNIVERSITY COLLEGE DUBLIN (IE) | 2001-04-19 | — | — | WO | claimed |
| EP-0958526-A1 | ELECTROCHROMIC SYSTEM | UNIVERSITY COLLEGE DUBLIN (IE) | 1999-11-24 | — | — | EP | claimed |
| WO-1998035267-A1 | ELECTROCHROMIC SYSTEM | UNIVERSITY COLLEGE DUBLIN (IE) | 1998-08-13 | — | — | WO | claimed |
| EP-1004143-B1 | CHARGE GENERATORS IN HETEROLAMELLAR MULTILAYER THIN FILMS | UNIV SOUTHERN CALIFORNIA (US) | 2012-09-05 | — | — | EP | disclosed |
| US-5480629-A | TREATING AN AQUEOUS SUSPENSION OF CATALYST WITH OXYGEN AND HYDROGEN SOURCES, SEPARATING THE CATALYST AND ISOLATING HYDROGEN PEROXIDE | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1996-01-02 | — | — | US | disclosed |
| WO-1995004743-A1 | ELECTRON ACCEPTOR COMPOSITIONS | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1995-02-16 | — | — | WO | disclosed |